GAD2

From Wikipedia, the free encyclopedia

Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

PDB rendering based on 2okk.

Available structures: 2okk

Identifiers

Symbol(s)

GAD2; GAD65; MGC161605; MGC161607

External IDs

OMIM: 138275 MGI: 95634 HomoloGene: 20223

EC number

4.1.1.15

Gene ontology
Molecular Function:	• glutamate decarboxylase activity • protein binding • lyase activity • carboxy-lyase activity
Cellular Component:	• membrane • axon • synapse
Biological Process:	• glutamate decarboxylation to succinate • synaptic transmission • carboxylic acid metabolic process • neurotransmitter biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000818 (mRNA)
NP_000809 (protein)

NM_008078 (mRNA)
NP_032104 (protein)

Location

Chr 10: 26.55 - 26.63 Mb

Chr 2: 22.47 - 22.54 Mb

Pubmed search

[1]

[2]

Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa), also known as GAD2, is a human gene.

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome.^[1]