GABRR2

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Gamma-aminobutyric acid (GABA) receptor, rho 2
Identifiers
Symbol(s) GABRR2;
External IDs OMIM: 137162 MGI: 95626 HomoloGene: 20471
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2570 14409
Ensembl ENSG00000111886 ENSMUSG00000023267
Uniprot P28476 Q3TV27
Refseq NM_002043 (mRNA)
NP_002034 (protein)		 NM_008076 (mRNA)
NP_032102 (protein)
Location Chr 6: 90.02 - 90.08 Mb Chr 4: 33.39 - 33.42 Mb
Pubmed search [1] [2]

Gamma-aminobutyric acid (GABA) receptor, rho 2, also known as GABRR2, is a human gene.[1]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR2 is a member of the rho subunit family[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: GABRR2 gamma-aminobutyric acid (GABA) receptor, rho 2.

[edit] Further reading

  • Cutting GR, Curristin S, Zoghbi H, et al. (1992). "Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4.". Genomics 12 (4): 801-6. PMID 1315307. 
  • Hackam AS, Wang TL, Guggino WB, Cutting GR (1997). "The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction.". J. Biol. Chem. 272 (21): 13750-7. PMID 9153229. 
  • Kusama T, Hatama K, Sakurai M, et al. (1999). "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation.". Neurosci. Lett. 255 (1): 17-20. PMID 9839716. 
  • Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.". Biochim. Biophys. Acta 1447 (2-3): 307-12. PMID 10542332. 
  • Billups D, Hanley JG, Orme M, et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B.". J. Neurosci. 20 (23): 8643-50. PMID 11102469. 
  • Sedelnikova A, Weiss DS (2002). "Phosphorylation of the recombinant rho1 GABA receptor.". Int. J. Dev. Neurosci. 20 (3-5): 237-46. PMID 12175859. 
  • Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2.". J. Biol. Chem. 278 (8): 6128-35. doi:10.1074/jbc.M205162200. PMID 12431995. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gamel-Didelon K, Kunz L, Fohr KJ, et al. (2003). "Molecular and physiological evidence for functional gamma-aminobutyric acid (GABA)-C receptors in growth hormone-secreting cells.". J. Biol. Chem. 278 (22): 20192-5. doi:10.1074/jbc.M301729200. PMID 12660236. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 

[edit] External links

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