GABRB2

From Wikipedia, the free encyclopedia

Gamma-aminobutyric acid (GABA) A receptor, beta 2

Identifiers

GABRB2; MGC119386; MGC119388; MGC119389

External IDs

OMIM: 600232 MGI: 95620 HomoloGene: 7327

Gene ontology
Molecular Function:	• GABA-A receptor activity • ion channel activity • extracellular ligand-gated ion channel activity • chloride channel activity • neurotransmitter receptor activity • chloride ion binding
Cellular Component:	• integral to plasma membrane • postsynaptic membrane
Biological Process:	• ion transport • gamma-aminobutyric acid signaling pathway • synaptic transmission

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000813 (mRNA)
NP_000804 (protein)

NM_172432 (mRNA)
NP_766020 (protein)

Location

Chr 5: 160.65 - 160.91 Mb

Chr 11: 42.26 - 42.47 Mb

Pubmed search

[1]

[2]

Gamma-aminobutyric acid (GABA) A receptor, beta 2, also known as GABRB2, is a human gene.^[1]

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

GABAA receptor

[edit] References

^ ^a ^b Entrez Gene: GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2.

[edit] Further reading

Moss SJ, Doherty CA, Huganir RL (1992). "Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor.". J. Biol. Chem. 267 (20): 14470-6. PMID 1321150.
Kellenberger S, Malherbe P, Sigel E (1993). "Function of the alpha 1 beta 2 gamma 2S gamma-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites.". J. Biol. Chem. 267 (36): 25660-3. PMID 1334482.
McKinley DD, Lennon DJ, Carter DB (1995). "Cloning, sequence analysis and expression of two forms of mRNA coding for the human beta 2 subunit of the GABAA receptor.". Brain Res. Mol. Brain Res. 28 (1): 175-9. PMID 7707873.
Russek SJ, Farb DH (1995). "Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform.". Genomics 23 (3): 528-33. doi:10.1006/geno.1994.1539. PMID 7851879.
Tögel M, Mossier B, Fuchs K, Sieghart W (1994). "gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties.". J. Biol. Chem. 269 (17): 12993-8. PMID 8175718.
Hadingham KL, Wingrove PB, Wafford KA, et al. (1994). "Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors.". Mol. Pharmacol. 44 (6): 1211-8. PMID 8264558.
Akbarian S, Huntsman MM, Kim JJ, et al. (1996). "GABAA receptor subunit gene expression in human prefrontal cortex: comparison of schizophrenics and controls.". Cereb. Cortex 5 (6): 550-60. PMID 8590827.
Longson D, Longson CM, Jones EG (1997). "Localization of CAM II kinase-alpha, GAD, GluR2 and GABA(A) receptor subunit mRNAs in the human entorhinal cortex.". Eur. J. Neurosci. 9 (4): 662-75. PMID 9153573.
Russek SJ (1999). "Evolution of GABA(A) receptor diversity in the human genome.". Gene 227 (2): 213-22. PMID 10023064.
Bonnert TP, McKernan RM, Farrar S, et al. (1999). "theta, a novel gamma-aminobutyric acid type A receptor subunit.". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891-6. PMID 10449790.
Brooks-Kayal AR, Shumate MD, Jin H, et al. (1999). "Human neuronal gamma-aminobutyric acid(A) receptors: coordinated subunit mRNA expression and functional correlates in individual dentate granule cells.". J. Neurosci. 19 (19): 8312-8. PMID 10493732.
Buckley ST, Eckert AL, Dodd PR (2006). "Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex.". Ann. N. Y. Acad. Sci. 914: 58-64. PMID 11085308.
Salim K, Fenton T, Bacha J, et al. (2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation.". J. Biol. Chem. 277 (18): 15482-5. doi:10.1074/jbc.M201539200. PMID 11854302.
Beck M, Brickley K, Wilkinson HL, et al. (2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1.". J. Biol. Chem. 277 (33): 30079-90. doi:10.1074/jbc.M200438200. PMID 12034717.
Iyer SP, Akimoto Y, Hart GW (2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase.". J. Biol. Chem. 278 (7): 5399-409. doi:10.1074/jbc.M209384200. PMID 12435728.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wang J, Liu S, Haditsch U, et al. (2003). "Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapses.". J. Neurosci. 23 (3): 826-36. PMID 12574411.
Pirker S, Schwarzer C, Czech T, et al. (2003). "Increased expression of GABA(A) receptor beta-subunits in the hippocampus of patients with temporal lobe epilepsy.". J. Neuropathol. Exp. Neurol. 62 (8): 820-34. PMID 14503638.
Mercik K, Pytel M, Mozrzymas JW (2004). "Recombinant alpha 1 beta 2 gamma 2 GABA(A) receptors expressed in HEK293 and in QT6 cells show different kinetics.". Neurosci. Lett. 352 (3): 195-8. PMID 14625018.
Lo WS, Lau CF, Xuan Z, et al. (2005). "Association of SNPs and haplotypes in GABAA receptor beta2 gene with schizophrenia.". Mol. Psychiatry 9 (6): 603-8. doi:10.1038/sj.mp.4001461. PMID 14699426.

[edit] External links

MeSH GABRB2+protein,+human

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Ion channel, receptor: ligand-gated ion channels

Cys-loop receptors	5-HT/serotonin: 5-HT₃ (A) GABA: GABA A (α₁, α₂, α₃, α₄, α₅, α₆, β₁, β₂, β₃, γ₂, γ₃, δ, ε, π), GABA C (ρ₁, ρ₂) Glycine: α₁, α₂, β Nicotinic acetylcholine: α1, α2, α3, α4, α5, α7, α9, β1, β2, β3, β4, δ, ε, combinations ((α4)₂(β2)₃, (α7)₅, Ganglion type, Muscle type)

Ionotropic glutamates	AMPA (1, 2, 3, 4) - Kainate (1, 2, 3, 5) - NMDA (1, 2A, 2B, 2C, 2D)

ATP-gated channels	Purinergic receptors: P2X (1, 2, 3, 4, 5, 6, 7)