GABARAP

From Wikipedia, the free encyclopedia

GABA(A) receptor-associated protein

PDB rendering based on 1gnu.

Available structures: 1gnu, 1kjt, 1klv, 1km7, 1kot

Identifiers

Symbol(s)

GABARAP; FLJ25768; MGC120154; MGC120155; MM46

External IDs

OMIM: 605125 MGI: 1861742 HomoloGene: 10508

Gene ontology
Molecular Function:	• protein binding • microtubule binding • beta-tubulin binding • GABA receptor binding
Cellular Component:	• lysosome • smooth endoplasmic reticulum • Golgi apparatus • microtubule • microtubule associated complex • plasma membrane • actin cytoskeleton
Biological Process:	• microtubule cytoskeleton organization and biogenesis • protein targeting • synaptic transmission • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007278 (mRNA)
NP_009209 (protein)

NM_019749 (mRNA)
NP_062723 (protein)

Location

Chr 17: 7.08 - 7.09 Mb

Chr 11: 69.81 - 69.81 Mb

Pubmed search

[1]

[2]

GABA(A) receptor-associated protein, also known as GABARAP, is a human gene.

Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.^[1]

[edit] References

^ Entrez Gene: GABARAP GABA(A) receptor-associated protein.

[edit] Further reading

Kanematsu T, Hirata M (2002). "[The analysis of protein-protein interaction with special reference to PRIP-1]". Nippon Yakurigaku Zasshi 119 (4): 241-6. PMID 11979730.
Wang H, Bedford FK, Brandon NJ, et al. (1999). "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton.". Nature 397 (6714): 69-72. doi:10.1038/16264. PMID 9892355.
Paz Y, Elazar Z, Fass D (2000). "Structure of GATE-16, membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7p.". J. Biol. Chem. 275 (33): 25445-50. doi:10.1074/jbc.C000307200. PMID 10856287.
Wang H, Olsen RW (2000). "Binding of the GABA(A) receptor-associated protein (GABARAP) to microtubules and microfilaments suggests involvement of the cytoskeleton in GABARAPGABA(A) receptor interaction.". J. Neurochem. 75 (2): 644-55. PMID 10899939.
Kneussel M, Haverkamp S, Fuhrmann JC, et al. (2000). "The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse.". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8594-9. PMID 10900017.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543-8. doi:10.1073/pnas.160270997. PMID 10931946.
Chen L, Wang H, Vicini S, Olsen RW (2000). "The gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kinetics.". Proc. Natl. Acad. Sci. U.S.A. 97 (21): 11557-62. doi:10.1073/pnas.190133497. PMID 10984509.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.
Okazaki N, Yan J, Yuasa S, et al. (2001). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.". Brain Res. Mol. Brain Res. 85 (1-2): 1-12. PMID 11146101.
Xin Y, Yu L, Chen Z, et al. (2001). "Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein.". Genomics 74 (3): 408-13. doi:10.1006/geno.2001.6555. PMID 11414770.
Kittler JT, Rostaing P, Schiavo G, et al. (2001). "The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABA(A) receptors.". Mol. Cell. Neurosci. 18 (1): 13-25. doi:10.1006/mcne.2001.1005. PMID 11461150.
Stangler T, Mayr LM, Dingley AJ, et al. (2002). "Sequence-specific 1H, 13C and 15N resonance assignments of human GABA receptor associated protein.". J. Biomol. NMR 21 (2): 183-4. PMID 11727985.
Harris R, McAlister MS, Sankar A, et al. (2002). "Backbone 1H, 13C, and 15N resonance assignments for a 14 kD protein, GABA(A) receptor associated protein (GABARAP).". J. Biomol. NMR 21 (2): 185-6. PMID 11727986.
Knight D, Harris R, McAlister MS, et al. (2002). "The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein.". J. Biol. Chem. 277 (7): 5556-61. doi:10.1074/jbc.M109753200. PMID 11729197.
Coyle JE, Qamar S, Rajashankar KR, Nikolov DB (2002). "Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding.". Neuron 33 (1): 63-74. PMID 11779480.
Tanida I, Tanida-Miyake E, Komatsu M, et al. (2002). "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.". J. Biol. Chem. 277 (16): 13739-44. doi:10.1074/jbc.M200385200. PMID 11825910.
Stangler T, Mayr LM, Willbold D (2002). "Solution structure of human GABA(A) receptor-associated protein GABARAP: implications for biolgoical funcrion and its regulation.". J. Biol. Chem. 277 (16): 13363-6. doi:10.1074/jbc.C200050200. PMID 11875056.
Kouno T, Miura K, Kanematsu T, et al. (2003). "1H, 13C and '5N resonance assignments of GABARAP, GABAA receptor associated protein.". J. Biomol. NMR 22 (1): 97-8. PMID 11885988.
Tanida I, Tanida-Miyake E, Nishitani T, et al. (2002). "Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs.". Biochem. Biophys. Res. Commun. 292 (1): 256-62. PMID 11890701.
Nymann-Andersen J, Wang H, Chen L, et al. (2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors.". J. Neurochem. 80 (5): 815-23. PMID 11948245.