GABARAPL2

From Wikipedia, the free encyclopedia

GABA(A) receptor-associated protein-like 2

PDB rendering based on 1eo6.

Available structures: 1eo6

Identifiers

Symbol(s)

GABARAPL2; ATG8; GEF-2; GEF2

External IDs

OMIM: 607452 MGI: 1890602 HomoloGene: 68550

Gene ontology
Molecular Function:	• actin binding • protein binding • ATP binding • beta-tubulin binding • GABA receptor binding
Cellular Component:	• intracellular • cytoskeleton • plasma membrane
Biological Process:	• protein targeting • synaptic transmission • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007285 (mRNA)
NP_009216 (protein)

NM_026693 (mRNA)
NP_080969 (protein)

Location

Chr 16: 74.16 - 74.17 Mb

Chr 8: 114.83 - 114.84 Mb

Pubmed search

[1]

[2]

GABA(A) receptor-associated protein-like 2, also known as GABARAPL2, is a human gene.^[1]

[edit] References

^ Entrez Gene: GABARAPL2 GABA(A) receptor-associated protein-like 2.

[edit] Further reading

Rohwer A, Kittstein W, Marks F, Gschwendt M (1999). "Cloning, expression and characterization of an A6-related protein.". Eur. J. Biochem. 263 (2): 518–25. PMID 10406962.
Sagiv Y, Legesse-Miller A, Porat A, Elazar Z (2000). "GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28.". EMBO J. 19 (7): 1494–504. doi:10.1093/emboj/19.7.1494. PMID 10747018.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Okazaki N, Yan J, Yuasa S, et al. (2001). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.". Brain Res. Mol. Brain Res. 85 (1-2): 1–12. PMID 11146101.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Xin Y, Yu L, Chen Z, et al. (2001). "Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein.". Genomics 74 (3): 408–13. doi:10.1006/geno.2001.6555. PMID 11414770.
Tanida I, Tanida-Miyake E, Nishitani T, et al. (2002). "Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs.". Biochem. Biophys. Res. Commun. 292 (1): 256–62. PMID 11890701.
Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z (2003). "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A.". J. Biol. Chem. 278 (16): 14053–8. doi:10.1074/jbc.M212108200. PMID 12473658.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Sou YS, Tanida I, Komatsu M, et al. (2006). "Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16.". J. Biol. Chem. 281 (6): 3017–24. doi:10.1074/jbc.M505888200. PMID 16303767.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.