GAB2

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GRB2-associated binding protein 2
Identifiers
Symbol(s) GAB2; KIAA0571
External IDs OMIM: 606203 MGI: 1333854 HomoloGene: 69067
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9846 14389
Ensembl ENSG00000033327 ENSMUSG00000004508
Uniprot Q9UQC2 Q3ZB56
Refseq NM_012296 (mRNA)
NP_036428 (protein)		 NM_010248 (mRNA)
NP_034378 (protein)
Location Chr 11: 77.6 - 77.81 Mb Chr 7: 96.96 - 97.18 Mb
Pubmed search [1] [2]

GRB2-associated binding protein 2, also known as GAB2, is a human gene.[1]

The protein encoded by this gene, GAB2 is an adaptor protein serving as principal activator of Phosphatidylinositol 3-kinase. 10 SNPs of GAB2 gene have been found in one study to associate with risk of Alzheimer's disease in the carriers of ApoE4 allele.[2]

[edit] References

  1. ^ Entrez Gene: GAB2 GRB2-associated binding protein 2.
  2. ^ Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert RH, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Heward CB, Ravid R, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Kukull W, Papassotiropoulos A, Stephan DA (2007). "GAB2 Alleles Modify Alzheimer's Risk in APOE varepsilon4 Carriers" 54 (5): 713–720. doi:10.1016/j.neuron.2007.05.022. PMID 17553421.  Free full text Free PDF Genetic data in the public domain

[edit] Further reading

  • Hibi M, Hirano T (2000). "Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors.". Leuk. Lymphoma 37 (3-4): 299–307. PMID 10752981. 
  • Gold MR, Ingham RJ, McLeod SJ, et al. (2001). "Targets of B-cell antigen receptor signaling: the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway and the Rap1 GTPase.". Immunol. Rev. 176: 47–68. PMID 11043767. 
  • Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. PMID 9628581. 
  • Nishida K, Yoshida Y, Itoh M, et al. (1999). "Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.". Blood 93 (6): 1809–16. PMID 10068651. 
  • Zhao C, Yu DH, Shen R, Feng GS (1999). "Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1.". J. Biol. Chem. 274 (28): 19649–54. PMID 10391903. 
  • Wickrema A, Uddin S, Sharma A, et al. (1999). "Engagement of Gab1 and Gab2 in erythropoietin signaling.". J. Biol. Chem. 274 (35): 24469–74. PMID 10455108. 
  • Bone H, Welham MJ (2000). "Shc associates with the IL-3 receptor beta subunit, SHIP and Gab2 following IL-3 stimulation. Contribution of Shc PTB and SH2 domains.". Cell. Signal. 12 (3): 183–94. PMID 10704825. 
  • Liu Y, Jenkins B, Shin JL, Rohrschneider LR (2001). "Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase.". Mol. Cell. Biol. 21 (9): 3047–56. doi:10.1128/MCB.21.9.3047-3056.2001. PMID 11287610. 
  • Crouin C, Arnaud M, Gesbert F, et al. (2001). "A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners.". FEBS Lett. 495 (3): 148–53. PMID 11334882. 
  • Bouscary D, Lecoq-Lafon C, Chrétien S, et al. (2001). "Role of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo).". Oncogene 20 (18): 2197–204. doi:10.1038/sj.onc.1204317. PMID 11402314. 
  • Wu C, Lai CF, Mobley WC (2001). "Nerve growth factor activates persistent Rap1 signaling in endosomes.". J. Neurosci. 21 (15): 5406–16. PMID 11466412. 
  • Yamasaki S, Nishida K, Hibi M, et al. (2002). "Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules.". J. Biol. Chem. 276 (48): 45175–83. doi:10.1074/jbc.M105384200. PMID 11572860. 
  • Yamada K, Nishida K, Hibi M, et al. (2001). "Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat.". Cytogenet. Cell Genet. 94 (1-2): 39–42. PMID 11701952. 
  • Lynch DK, Daly RJ (2002). "PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.". EMBO J. 21 (1-2): 72–82. PMID 11782427. 
  • Wheadon H, Paling NR, Welham MJ (2002). "Molecular interactions of SHP1 and SHP2 in IL-3-signalling.". Cell. Signal. 14 (3): 219–29. PMID 11812650. 
  • Dorsey JF, Cunnick JM, Mane SM, Wu J (2002). "Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562 leukemic cells by Gab2.". Blood 99 (4): 1388–97. PMID 11830491. 
  • Hill RJ, Zozulya S, Lu YL, et al. (2002). "The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation.". Exp. Hematol. 30 (3): 237–44. PMID 11882361. 
  • Yu WM, Hawley TS, Hawley RG, Qu CK (2002). "Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration.". Blood 99 (7): 2351–9. PMID 11895767. 

[edit] External links

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