GAB1

From Wikipedia, the free encyclopedia


GRB2-associated binding protein 1
Identifiers
Symbol(s) GAB1;
External IDs OMIM: 604439 MGI: 108088 HomoloGene: 1542
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2549 14388
Ensembl ENSG00000109458 ENSMUSG00000031714
Uniprot Q13480 Q505A4
Refseq NM_002039 (mRNA)
NP_002030 (protein)		 NM_021356 (mRNA)
NP_067331 (protein)
Location Chr 4: 144.48 - 144.61 Mb Chr 8: 83.66 - 83.78 Mb
Pubmed search [1] [2]

GRB2-associated binding protein 1, also known as GAB1, is a human gene.

The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. The encoded protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.[1]

[edit] References

  1. ^ Entrez Gene: GAB1 GRB2-associated binding protein 1.


[edit] Further reading

  • Holgado-Madruga M, Emlet DR, Moscatello DK, et al. (1996). "A Grb2-associated docking protein in EGF- and insulin-receptor signalling.". Nature 379 (6565): 560–4. doi:10.1038/379560a0. PMID 8596638. 
  • Fixman ED, Holgado-Madruga M, Nguyen L, et al. (1997). "Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.". J. Biol. Chem. 272 (32): 20167–72. PMID 9242692. 
  • Nguyen L, Holgado-Madruga M, Maroun C, et al. (1997). "Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.". J. Biol. Chem. 272 (33): 20811–9. PMID 9252406. 
  • Holgado-Madruga M, Moscatello DK, Emlet DR, et al. (1997). "Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor.". Proc. Natl. Acad. Sci. U.S.A. 94 (23): 12419–24. PMID 9356464. 
  • Rocchi S, Tartare-Deckert S, Murdaca J, et al. (1998). "Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules.". Mol. Endocrinol. 12 (7): 914–23. PMID 9658397. 
  • Qiu M, Hua S, Agrawal M, et al. (1999). "Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1.". Biochem. Biophys. Res. Commun. 253 (2): 443–7. doi:10.1006/bbrc.1998.9795. PMID 9878555. 
  • Lehr S, Kotzka J, Herkner A, et al. (1999). "Identification of tyrosine phosphorylation sites in human Gab-1 protein by EGF receptor kinase in vitro.". Biochemistry 38 (1): 151–9. doi:10.1021/bi9818265. PMID 9890893. 
  • Maroun CR, Holgado-Madruga M, Royal I, et al. (1999). "The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase.". Mol. Cell. Biol. 19 (3): 1784–99. PMID 10022866. 
  • Nishida K, Yoshida Y, Itoh M, et al. (1999). "Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.". Blood 93 (6): 1809–16. PMID 10068651. 
  • Gual P, Giordano S, Williams TA, et al. (2000). "Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis.". Oncogene 19 (12): 1509–18. doi:10.1038/sj.onc.1203514. PMID 10734310. 
  • Braun L, Ghebrehiwet B, Cossart P (2000). "gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes.". EMBO J. 19 (7): 1458–66. doi:10.1093/emboj/19.7.1458. PMID 10747014. 
  • Sakkab D, Lewitzky M, Posern G, et al. (2000). "Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL.". J. Biol. Chem. 275 (15): 10772–8. PMID 10753869. 
  • Lehr S, Kotzka J, Herkner A, et al. (2000). "Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro.". Biochemistry 39 (35): 10898–907. PMID 10978177. 
  • Sachs M, Brohmann H, Zechner D, et al. (2000). "Essential role of Gab1 for signaling by the c-Met receptor in vivo.". J. Cell Biol. 150 (6): 1375–84. PMID 10995442. 
  • Yart A, Laffargue M, Mayeux P, et al. (2001). "A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.". J. Biol. Chem. 276 (12): 8856–64. doi:10.1074/jbc.M006966200. PMID 11134009. 
  • Ingham RJ, Santos L, Dang-Lawson M, et al. (2001). "The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase.". J. Biol. Chem. 276 (15): 12257–65. doi:10.1074/jbc.M010590200. PMID 11278704. 
  • Lewitzky M, Kardinal C, Gehring NH, et al. (2001). "The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif.". Oncogene 20 (9): 1052–62. doi:10.1038/sj.onc.1204202. PMID 11314042. 
  • Cunnick JM, Mei L, Doupnik CA, Wu J (2001). "Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.". J. Biol. Chem. 276 (26): 24380–7. doi:10.1074/jbc.M010275200. PMID 11323411. 
  • Kurokawa K, Iwashita T, Murakami H, et al. (2001). "Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction.". Oncogene 20 (16): 1929–38. doi:10.1038/sj.onc.1204290. PMID 11360177. 
  • Kameda H, Risinger JI, Han BB, et al. (2001). "Identification of epidermal growth factor receptor- Grb2-associated binder-1-SHP-2 complex formation and its functional loss during neoplastic cell progression.". Cell Growth Differ. 12 (6): 307–18. PMID 11432805. 
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