FZR1

From Wikipedia, the free encyclopedia

Fizzy/cell division cycle 20 related 1 (Drosophila)

Identifiers

FZR1; CDH1; CDC20C; FZR; FZR2; HCDH; HCDH1; KIAA1242

External IDs

OMIM: 603619 MGI: 1926790 HomoloGene: 9444

Gene ontology
Molecular Function:	• protein binding • enzyme activator activity
Cellular Component:	• anaphase-promoting complex
Biological Process:	• regulation of progression through cell cycle • ubiquitin-dependent protein catabolic process • ubiquitin cycle • cell cycle • mitosis • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016263 (mRNA)
NP_057347 (protein)

NM_019757 (mRNA)
NP_062731 (protein)

Location

Chr 19: 3.46 - 3.49 Mb

Chr 10: 80.77 - 80.78 Mb

Pubmed search

[1]

[2]

Fizzy/cell division cycle 20 related 1 (Drosophila), also known as FZR1, is a human gene.^[1]

[edit] References

^ Entrez Gene: FZR1 fizzy/cell division cycle 20 related 1 (Drosophila).

[edit] Further reading

Fang G, Yu H, Kirschner MW (1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1.". Mol. Cell 2 (2): 163-71. PMID 9734353.
Kramer ER, Gieffers C, Hölzl G, et al. (1999). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family.". Curr. Biol. 8 (22): 1207-10. PMID 9811605.
Kotani S, Tanaka H, Yasuda H, Todokoro K (1999). "Regulation of APC activity by phosphorylation and regulatory factors.". J. Cell Biol. 146 (4): 791-800. PMID 10459014.
Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons.". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317-22. PMID 10500174.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337-45. PMID 10574462.
Sorensen CS, Lukas C, Kramer ER, et al. (2000). "Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis.". Mol. Cell. Biol. 20 (20): 7613-23. PMID 11003657.
Bembenek J, Yu H (2002). "Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a.". J. Biol. Chem. 276 (51): 48237-42. doi:10.1074/jbc.M108126200. PMID 11598127.
Stroschein SL, Bonni S, Wrana JL, Luo K (2001). "Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN.". Genes Dev. 15 (21): 2822-36. doi:10.1101/gad.912901. PMID 11691834.
Hsu JY, Reimann JD, Sørensen CS, et al. (2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1).". Nat. Cell Biol. 4 (5): 358-66. doi:10.1038/ncb785. PMID 11988738.
Zur A, Brandeis M (2002). "Timing of APC/C substrate degradation is determined by fzy/fzr specificity of destruction boxes.". EMBO J. 21 (17): 4500-10. PMID 12198152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhou Y, Ching YP, Chun AC, Jin DY (2003). "Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylation.". J. Biol. Chem. 278 (14): 12530-6. doi:10.1074/jbc.M212853200. PMID 12560341.
Zhou Y, Ching YP, Ng RW, Jin DY (2003). "Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1.". Biochem. J. 374 (Pt 2): 349-58. doi:10.1042/BJ20030600. PMID 12797865.
Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.". Curr. Biol. 13 (17): 1459-68. PMID 12956947.
Wei W, Ayad NG, Wan Y, et al. (2004). "Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.". Nature 428 (6979): 194-8. doi:10.1038/nature02381. PMID 15014503.
Listovsky T, Oren YS, Yudkovsky Y, et al. (2005). "Mammalian Cdh1/Fzr mediates its own degradation.". EMBO J. 23 (7): 1619-26. doi:10.1038/sj.emboj.7600149. PMID 15029244.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
Nourry C, Maksumova L, Pang M, et al. (2005). "Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1.". BMC Cell Biol. 5: 20. doi:10.1186/1471-2121-5-20. PMID 15144564.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kraft C, Vodermaier HC, Maurer-Stroh S, et al. (2005). "The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.". Mol. Cell 18 (5): 543-53. doi:10.1016/j.molcel.2005.04.023. PMID 15916961.