FYVE domain
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Early endosome antigen 1 (EEA1) dimer with lipids | ||
FYVE zinc finger | ||
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Identifiers | ||
Symbol | FYVE | |
Pfam | PF01363 | |
InterPro | IPR000306 | |
PROSITE | PDOC50178 | |
SCOP | 1vfy | |
OPM family | 62 | |
OPM protein | 1vfy | |
Available PDB structures:
1dvpA:156-219 1vfyA:168-230 1jocB:1347-1411 1hyjA:1347-1411 1hyiA:1347-1411 1wfkA:2-59 1x4uA:349-411 |
FYVE zinc finger domain is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1.
The FYVE finger binds two zinc ions. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. FYVE domains bind Phosphatidylinositol 3-phosphate.
The FYVE finger is structural similarity to RING domain and PHD finger.
[edit] Human proteins containing this domain
ANKFY1; EEA1; FGD1; FGD2; FGD3; FGD4; FGD5; FGD6; FYCO1; HGS; MTMR3; MTMR4; PIP5K3; PLEKHF1; PLEKHF2; RUFY1; RUFY2; WDF3; WDFY1; WDFY2; WDFY3; ZFYVE1; ZFYVE16; ZFYVE19; ZFYVE20; ZFYVE21; ZFYVE26; ZFYVE27; ZFYVE28; ZFYVE9;
[edit] References
- [1]. Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. Stenmark H, Aasland R, Toh BH, D'Arrigo A; J Biol Chem 1996;271:24048-24054. PubMed
- [2]. FYVE fingers bind PtdIns(3)P. Gaullier JM, Simonsen A, D'Arrigo A, Bremnes B, Stenmark H, Aasland R; Nature 1998;394:432-433. PubMed
- [3]. FYVE-finger proteins - effectors of an inositol lipid. Stenmark H, Aasland R; J Cell Sci 1999;112:4175-4183. PubMed
[edit] External links
- Zinc finger FYVE/FYVE-related type in PROSITE
- FYVE domain in Pfam
- UMich Orientation of Proteins in Membranes families/superfamily-62 - Orientations of FYVE/PHD zinc finger domains in membranes (OPM)
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