FYB

From Wikipedia, the free encyclopedia

FYN binding protein (FYB-120/130)

PDB rendering based on 1ri9.

Available structures: 1ri9, 2gtj, 2gto

Identifiers

Symbol(s)

FYB; ADAP; PRO0823; SLAP-130

External IDs

OMIM: 602731 MGI: 1346327 HomoloGene: 22664

Gene ontology
Molecular Function:	• receptor binding • protein binding
Cellular Component:	• nucleus • actin cytoskeleton
Biological Process:	• protein amino acid phosphorylation • NLS-bearing substrate import into nucleus • immune response • signal transduction • protein kinase cascade • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001465 (mRNA)
NP_001456 (protein)

XM_974556 (mRNA)
XP_979650 (protein)

Location

Chr 5: 39.14 - 39.26 Mb

Chr 15: 6.53 - 6.61 Mb

Pubmed search

[1]

[2]

FYN binding protein (FYB-120/130), also known as FYB, is a human gene.^[1]

[edit] References

^ Entrez Gene: FYB FYN binding protein (FYB-120/130).

[edit] Further reading

da Silva AJ, Janssen O, Rudd CE (1993). "T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T).". J. Exp. Med. 178 (6): 2107-13. PMID 7504057.
Musci MA, Hendricks-Taylor LR, Motto DG, et al. (1997). "Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases.". J. Biol. Chem. 272 (18): 11674-7. PMID 9115214.
da Silva AJ, Li Z, de Vera C, et al. (1997). "Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7493-8. PMID 9207119.
Liu J, Kang H, Raab M, et al. (1998). "FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells.". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8779-84. PMID 9671755.
Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ, et al. (1998). "Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130.". J. Biol. Chem. 273 (40): 25789-95. PMID 9748251.
Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B (1998). "SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55.". FEBS Lett. 435 (1): 55-60. PMID 9755858.
Veale M, Raab M, Li Z, et al. (1999). "Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production.". J. Biol. Chem. 274 (40): 28427-35. PMID 10497204.
Hamid N, Gustavsson A, Andersson K, et al. (1999). "YopH dephosphorylates Cas and Fyn-binding protein in macrophages.". Microb. Pathog. 27 (4): 231-42. doi:10.1006/mpat.1999.0301. PMID 10502464.
Geng L, Raab M, Rudd CE (1999). "Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651.". J. Immunol. 163 (11): 5753-7. PMID 10570256.
Krause M, Sechi AS, Konradt M, et al. (2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton.". J. Cell Biol. 149 (1): 181-94. PMID 10747096.
Kang H, Freund C, Duke-Cohan JS, et al. (2000). "SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55.". EMBO J. 19 (12): 2889-99. doi:10.1093/emboj/19.12.2889. PMID 10856234.
Asazuma N, Wilde JI, Berlanga O, et al. (2000). "Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.". J. Biol. Chem. 275 (43): 33427-34. doi:10.1074/jbc.M001439200. PMID 10942756.
Li C, Iosef C, Jia CY, et al. (2003). "Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors.". J. Biol. Chem. 278 (6): 3852-9. doi:10.1074/jbc.M206649200. PMID 12458214.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763-72. doi:10.1021/ac035352d. PMID 15144186.
Heuer K, Arbuzova A, Strauss H, et al. (2005). "The helically extended SH3 domain of the T cell adaptor protein ADAP is a novel lipid interaction domain.". J. Mol. Biol. 348 (4): 1025-35. doi:10.1016/j.jmb.2005.02.069. PMID 15843031.
Huang Y, Norton DD, Precht P, et al. (2005). "Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells.". J. Biol. Chem. 280 (25): 23576-83. doi:10.1074/jbc.M413201200. PMID 15849195.
Koga S, Yogo K, Yoshikawa K, et al. (2005). "Physical and functional association of c-Src and adhesion and degranulation promoting adaptor protein (ADAP) in osteoclastogenesis in vitro.". J. Biol. Chem. 280 (36): 31564-71. doi:10.1074/jbc.M502703200. PMID 16020549.
Duke-Cohan JS, Kang H, Liu H, Rudd CE (2006). "Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein.". J. Biol. Chem. 281 (19): 13743-50. doi:10.1074/jbc.M508774200. PMID 16461356.