FXYD3

From Wikipedia, the free encyclopedia

FXYD domain containing ion transport regulator 3

Identifiers

FXYD3; MAT-8; MAT8; MGC111076; PLML

External IDs

OMIM: 604996 MGI: 107497 HomoloGene: 4356

Gene ontology
Molecular Function:	• ion channel activity • chloride channel activity • chloride ion binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• ion transport • chloride transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005971 (mRNA)
NP_005962 (protein)

NM_008557 (mRNA)
NP_032583 (protein)

Location

Chr 19: 40.3 - 40.31 Mb

Chr 7: 30.78 - 30.79 Mb

Pubmed search

[1]

[2]

FXYD domain containing ion transport regulator 3, also known as FXYD3, is a human gene.^[1]

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene may function as a chloride channel or as a chloride channel regulator. Two transcript variants encode two different isoforms of the protein; in addition, transcripts utilizing alternative polyA signals have been described in the literature.^[1]

[edit] References

^ ^a ^b Entrez Gene: FXYD3 FXYD domain containing ion transport regulator 3.

[edit] Further reading

Morrison BW, Moorman JR, Kowdley GC, et al. (1995). "Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes.". J. Biol. Chem. 270 (5): 2176-82. PMID 7836447.
Sweadner KJ, Rael E (2001). "The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression.". Genomics 68 (1): 41-56. doi:10.1006/geno.2000.6274. PMID 10950925.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Crowell KJ, Franzin CM, Koltay A, et al. (2003). "Expression and characterization of the FXYD ion transport regulators for NMR structural studies in lipid micelles and lipid bilayers.". Biochim. Biophys. Acta 1645 (1): 15-21. PMID 12535606.
Grzmil M, Voigt S, Thelen P, et al. (2004). "Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells.". Int. J. Oncol. 24 (1): 97-105. PMID 14654946.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kayed H, Kleeff J, Kolb A, et al. (2005). "FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth.". Int. J. Cancer 118 (1): 43-54. doi:10.1002/ijc.21257. PMID 16003754.
Franzin CM, Yu J, Thai K, et al. (2006). "Correlation of gene and protein structures in the FXYD family proteins.". J. Mol. Biol. 354 (4): 743-50. doi:10.1016/j.jmb.2005.10.018. PMID 16288923.
Bibert S, Roy S, Schaer D, et al. (2007). "Structural and functional properties of two human FXYD3 (Mat-8) isoforms.". J. Biol. Chem. 281 (51): 39142-51. doi:10.1074/jbc.M605221200. PMID 17077088.
Arimochi J, Ohashi-Kobayashi A, Maeda M (2007). "Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells.". Biol. Pharm. Bull. 30 (4): 648-54. PMID 17409496.