FXR1

From Wikipedia, the free encyclopedia

Fragile X mental retardation, autosomal homolog 1

PDB rendering based on 2cpq.

Available structures: 2cpq

Identifiers

Symbol(s)

FXR1;

External IDs

OMIM: 600819 MGI: 104860 HomoloGene: 3573

Gene ontology
Molecular Function:	• RNA binding
Cellular Component:	• nucleolus • cytoplasm • polysome • costamere
Biological Process:	• apoptosis • multicellular organismal development • striated muscle development • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001013438 (mRNA)
NP_001013456 (protein)

NM_008053 (mRNA)
NP_032079 (protein)

Location

Chr 3: 182.11 - 182.18 Mb

Chr 3: 34.21 - 34.26 Mb

Pubmed search

[1]

[2]

Fragile X mental retardation, autosomal homolog 1, also known as FXR1, is a human gene.^[1]

The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: FXR1 fragile X mental retardation, autosomal homolog 1.

[edit] Further reading

Zhang Y, O'Connor JP, Siomi MC, et al. (1996). "The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.". EMBO J. 14 (21): 5358–66. PMID 7489725.
Siomi MC, Siomi H, Sauer WH, et al. (1995). "FXR1, an autosomal homolog of the fragile X mental retardation gene.". EMBO J. 14 (11): 2401–8. PMID 7781595.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Coy JF, Sedlacek Z, Bächner D, et al. (1996). "Highly conserved 3' UTR and expression pattern of FXR1 points to a divergent gene regulation of FXR1 and FMR1.". Hum. Mol. Genet. 4 (12): 2209–18. PMID 8634689.
Siomi MC, Zhang Y, Siomi H, Dreyfuss G (1996). "Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them.". Mol. Cell. Biol. 16 (7): 3825–32. PMID 8668200.
Tamanini F, Willemsen R, van Unen L, et al. (1997). "Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.". Hum. Mol. Genet. 6 (8): 1315–22. PMID 9259278.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Bolívar J, Guelman S, Iglesias C, et al. (1998). "The fragile-X-related gene FXR1 is a human autoantigen processed during apoptosis.". J. Biol. Chem. 273 (27): 17122–7. PMID 9642279.
Khandjian EW, Bardoni B, Corbin F, et al. (1999). "Novel isoforms of the fragile X related protein FXR1P are expressed during myogenesis.". Hum. Mol. Genet. 7 (13): 2121–8. PMID 9817930.
Tamanini F, Bontekoe C, Bakker CE, et al. (1999). "Different targets for the fragile X-related proteins revealed by their distinct nuclear localizations.". Hum. Mol. Genet. 8 (5): 863–9. PMID 10196376.
Tamanini F, Van Unen L, Bakker C, et al. (2000). "Oligomerization properties of fragile-X mental-retardation protein (FMRP) and the fragile-X-related proteins FXR1P and FXR2P.". Biochem. J. 343 Pt 3: 517–23. PMID 10527928.
Bardoni B, Schenck A, Mandel JL (2000). "A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein.". Hum. Mol. Genet. 8 (13): 2557–66. PMID 10556305.
Ceman S, Brown V, Warren ST (2000). "Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex.". Mol. Cell. Biol. 19 (12): 7925–32. PMID 10567518.
Tamanini F, Kirkpatrick LL, Schonkeren J, et al. (2000). "The fragile X-related proteins FXR1P and FXR2P contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins.". Hum. Mol. Genet. 9 (10): 1487–93. PMID 10888599.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Schenck A, Bardoni B, Moro A, et al. (2001). "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.". Proc. Natl. Acad. Sci. U.S.A. 98 (15): 8844–9. doi:10.1073/pnas.151231598. PMID 11438699.
Kirkpatrick LL, McIlwain KA, Nelson DL (2002). "Comparative genomic sequence analysis of the FXR gene family: FMR1, FXR1, and FXR2.". Genomics 78 (3): 169–77. doi:10.1006/geno.2001.6667. PMID 11735223.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.". Exp. Cell Res. 288 (1): 35–50. PMID 12878157.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.