FVT1

From Wikipedia, the free encyclopedia

Follicular lymphoma variant translocation 1

Identifiers

External IDs

OMIM: 136440 MGI: 1918000 HomoloGene: 1539

Gene ontology
Molecular Function:	• oxidoreductase activity • 3-dehydrosphinganine reductase activity
Cellular Component:	• extracellular space • endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002035 (mRNA)
NP_002026 (protein)

XM_203753 (mRNA)
XP_203753 (protein)

Location

Chr 18: 59.15 - 59.19 Mb

Chr 1: 108.55 - 108.59 Mb

Pubmed search

[1]

[2]

Follicular lymphoma variant translocation 1, also known as FVT1, is a human gene.^[1]

Follicular lymphoma variant translocation 1 is a secreted protein which is weakly expressed in hematopoietic tissue. FVT1 shows a high rate of transcription in some T-cell malignancies and in phytohemagglutinin-stimulated lymphocytes. The proximity of FVT1 to BCL2 suggests that it may participate in the tumoral process^[1]

[edit] References

^ ^a ^b Entrez Gene: FVT1 follicular lymphoma variant translocation 1.

[edit] Further reading

Krebs S, Medugorac I, Röther S, et al. (2007). "A missense mutation in the 3-ketodihydrosphingosine reductase FVT1 as candidate causal mutation for bovine spinal muscular atrophy.". Proc. Natl. Acad. Sci. U.S.A. 104 (16): 6746–51. doi:10.1073/pnas.0607721104. PMID 17420465.
Quintero-Ramos A, Valdez-Vélázquez LL, Hernández G, et al. (2006). "[Assessment of five thrombophilic genetic polymorphisms among couples with habitual abortion]". Gaceta médica de México 142 (2): 95–8. PMID 16711541.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kihara A, Igarashi Y (2005). "FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane.". J. Biol. Chem. 279 (47): 49243–50. doi:10.1074/jbc.M405915200. PMID 15328338.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wang J, Blakey GL, Zhang L, et al. (2004). "Uterine tumor resembling ovarian sex cord tumor: report of a case with t(X;6)(p22.3;q23.1) and t(4;18)(q21.1;q21.3).". Diagn. Mol. Pathol. 12 (3): 174–80. PMID 12960700.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Rimokh R, Gadoux M, Berthéas MF, et al. (1993). "FVT-1, a novel human transcription unit affected by variant translocation t(2;18)(p11;q21) of follicular lymphoma.". Blood 81 (1): 136–42. PMID 8417785.
Nacheva E, Dyer MJ, Metivier C, et al. (1994). "B-cell non-Hodgkin's lymphoma cell line (Karpas 1106) with complex translocation involving 18q21.3 but lacking BCL2 rearrangement and expression.". Blood 84 (10): 3422–8. PMID 7949096.