FUS

From Wikipedia, the free encyclopedia

Fusion (involved in t(12;16) in malignant liposarcoma)

Identifiers

FUS; CHOP; FUS-CHOP; FUS1; TLS; TLS/CHOP

External IDs

OMIM: 137070 MGI: 1353633 HomoloGene: 3639

Gene ontology
Molecular Function:	• nucleotide binding • molecular_function • nucleic acid binding • DNA binding • RNA binding • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• cellular_component • intracellular • nucleus
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001010850 (mRNA)
NP_001010850 (protein)

XM_986259 (mRNA)
XP_991353 (protein)

Location

Chr 16: 31.1 - 31.11 Mb

Chr 7: 127.76 - 127.77 Mb

Pubmed search

[1]

[2]

Fusion (involved in t(12;16) in malignant liposarcoma), also known as FUS, is a human gene.^[1]

[edit] References

^ Entrez Gene: FUS fusion (involved in t(12;16) in malignant liposarcoma).

[edit] Further reading

Kaplowitz N, Ji C (2007). "Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum.". J. Gastroenterol. Hepatol. 21 Suppl 3: S7–9. doi:10.1111/j.1440-1746.2006.04581.x. PMID 16958678.
Eneroth M, Mandahl N, Heim S, et al. (1990). "Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2.". Cancer Genet. Cytogenet. 48 (1): 101–7. PMID 2372777.
Rabbitts TH, Forster A, Larson R, Nathan P (1993). "Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.". Nat. Genet. 4 (2): 175–80. doi:10.1038/ng0693-175. PMID 7503811.
Panagopoulos I, Mandahl N, Ron D, et al. (1995). "Characterization of the CHOP breakpoints and fusion transcripts in myxoid liposarcomas with the 12;16 translocation.". Cancer Res. 54 (24): 6500–3. PMID 7987849.
Ichikawa H, Shimizu K, Hayashi Y, Ohki M (1994). "An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.". Cancer Res. 54 (11): 2865–8. PMID 8187069.
Crozat A, Aman P, Mandahl N, Ron D (1993). "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.". Nature 363 (6430): 640–4. doi:10.1038/363640a0. PMID 8510758.
Aman P, Panagopoulos I, Lassen C, et al. (1997). "Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS.". Genomics 37 (1): 1–8. doi:10.1006/geno.1996.0513. PMID 8921363.
Zinszner H, Sok J, Immanuel D, et al. (1997). "TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling.". J. Cell. Sci. 110 ( Pt 15): 1741–50. PMID 9264461.
Powers CA, Mathur M, Raaka BM, et al. (1998). "TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors.". Mol. Endocrinol. 12 (1): 4–18. PMID 9440806.
Hallier M, Lerga A, Barnache S, et al. (1998). "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS.". J. Biol. Chem. 273 (9): 4838–42. PMID 9478924.
Zhang D, Paley AJ, Childs G (1998). "The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.". J. Biol. Chem. 273 (29): 18086–91. PMID 9660765.
Yang L, Embree LJ, Tsai S, Hickstein DD (1998). "Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing.". J. Biol. Chem. 273 (43): 27761–4. PMID 9774382.
Morohoshi F, Ootsuka Y, Arai K, et al. (1998). "Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.". Gene 221 (2): 191–8. PMID 9795213.
Bertrand P, Akhmedov AT, Delacote F, et al. (1999). "Human POMp75 is identified as the pro-oncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation.". Oncogene 18 (31): 4515–21. doi:10.1038/sj.onc.1203048. PMID 10442642.
Baechtold H, Kuroda M, Sok J, et al. (1999). "Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation.". J. Biol. Chem. 274 (48): 34337–42. PMID 10567410.
Yang L, Embree LJ, Hickstein DD (2000). "TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins.". Mol. Cell. Biol. 20 (10): 3345–54. PMID 10779324.
Husi H, Ward MA, Choudhary JS, et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698.
Uranishi H, Tetsuka T, Yamashita M, et al. (2001). "Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator.". J. Biol. Chem. 276 (16): 13395–401. doi:10.1074/jbc.M011176200. PMID 11278855.
Saunders LR, Perkins DJ, Balachandran S, et al. (2001). "Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR.". J. Biol. Chem. 276 (34): 32300–12. doi:10.1074/jbc.M104207200. PMID 11438536.
Lee J, Bedford MT (2002). "PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays.". EMBO Rep. 3 (3): 268–73. doi:10.1093/embo-reports/kvf052. PMID 11850402.