Fumarate reductase

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Fumarate reductase respiratory complex
Identifiers
Symbol Fum_red_TM
Pfam PF02967
InterPro IPR004224
SCOP 1qla
OPM family 3
OPM protein 2bs3
Available PDB structures:

1qlaF:1-243 2bs3F:1-243 1qlbC:1-243 2bs4F:1-243

Fumarate reductase is the enzyme that converts fumarate to succinate, it is important in microbial metabolism as a means for anaerobic respiration.[1]

Succinate + acceptor <=> fumarate + reduced acceptor

In other words, fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalysed by the related complex II of the respiratory chain (succinate dehydrogenase)[2].

Fumarate reductase complex includes three subunits. Subunit A contains the site of fumarate reduction and a covalently bound flavin adenine dinucleotide prosthetic group. Subunit B contains three iron-sulphur centres. The menaquinol-oxidizing subunit C consists of five membrane-spanning, primarily helical segments and binds two haem b molecules[2].

[edit] See also

[edit] References

  1. ^ Iverson TM, Luna-Chavez C, Cecchini G, Rees DC (1999). "Structure of the Escherichia coli fumarate reductase respiratory complex". Science 284 (5422): 1961–6. doi:10.1126/science.284.5422.1961. PMID 10373108. 
  2. ^ a b Michel H, Lancaster CR, Kroger A, Auer M (1999). "Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution". Nature 402 (6760): 377–385. doi:10.1038/45133. PMID 10586875. 

[edit] External links

v • d • e
Oxidoreductases: CH-CH oxidoreductases (EC 1.3)
1.3.1. NAD/NADP acceptor
1.3.3. Oxygen acceptor
1.3.5. Quinone
1.3.99. Other acceptors

This article includes text from the public domain Pfam and InterPro IPR004224