Fumarate hydratase

From Wikipedia, the free encyclopedia

In enzymology, a fumarate hydratase (EC 4.2.1.2) is an enzyme that catalyzes the chemical reaction

(S)-malate fumarate + H₂O

Hence, this enzyme has one substrate, (S)-malate, and two products, fumarate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (S)-malate hydro-lyase (fumarate-forming). Other names in common use include fumarase, L-malate hydro-lyase, and (S)-malate hydro-lyase. This enzyme participates in 3 metabolic pathways: citrate cycle (tca cycle), reductive carboxylate cycle (co2 fixation), and renal cell carcinoma.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1FUO, 1FUP, 1FUQ, 1FUR, 1KQ7, 1VDK, 1YFE, 1YFM, 2FUS, and 2ISB.

[edit] References

• IUBMB entry for 4.2.1.2
• BRENDA references for 4.2.1.2 (Recommended.)
• PubMed references for 4.2.1.2
• PubMed Central references for 4.2.1.2
• Google Scholar references for 4.2.1.2
• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 5, Academic Press, New York, 1961, p. 531-544.
• KANAREK L, HILL RL (1964). "THE PREPARATION AND CHARACTERIZATION OF FUMARASE FROM SWINE HEART MUSCLE". J. Biol. Chem. 239: 4202–6. PMID 14247669. 

[edit] External links

The CAS registry number for this enzyme class is 9032-88-6.

• IUBMB entry for 4.2.1.2

• KEGG entry for 4.2.1.2

• BRENDA entry for 4.2.1.2

• NiceZyme view of 4.2.1.2

• EC2PDB: PDB structures for 4.2.1.2

• PRIAM entry for 4.2.1.2

• PUMA2 entry for 4.2.1.2

• IntEnz: Integrated Enzyme entry for 4.2.1.2

• MetaCyc entry for 4.2.1.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004333: fumarate hydratase

• AMIGO entry for GO code 0004333: fumarate hydratase