Fumagillin
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Fumagillin
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| Systematic (IUPAC) name | |
| (2E,4E,6E,8E)-10-{[(3S,4S,5S,6R)- 5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl) oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy}- 10-oxo-deca-2,4,6,8-tetraenoic acid |
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| Identifiers | |
| CAS number | |
| ATC code | P01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C26H36O7 |
| Mol. mass | 460.566 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Fumagillin is an antibiotic originally used against fungal Nosema apis infections in honeybees. Some studies found it to be effective against some myxozoan parasites, including Myxobolus cerebralis, an important parasite of fish; however, in the more rigorous tests required for U.S. Food and Drug Administration approval, it was ineffective. Fumagillin can block blood vessel formation by binding to an enzyme called methionine aminopeptidase 2.[1]
There are reports that Fumagillin might play a role in controlling Nosema ceranae, which has recently been hypothesized as a possible cause of Colony Collapse Disorder.[2][3]
[edit] References
- ^ Gilbert, M. A. & Granath, W.O. Jr. (2003). "Whirling disease and salmonid fish: life cycle, biology, and disease". Journal of Parasitology 89 (4): pp. 658–667. doi:.
- ^ Sabin Russell. "UCSF scientist tracks down suspect in honeybee deaths", San Francisco Chronicle, 2007-04-26. (English)
- ^ "Scientists Identify Pathogens That May Be Causing Global Honeybee Deaths", PR Newswire, 2007-04-25. (English)
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