Fujimoto-Belleau reaction
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The Fujimoto-Belleau reaction is a chemical reaction that forms cyclic α-substituted α,β-unsaturated ketones from enol lactones. The reaction is named after the two chmists George I. Fujimoto and Bernard Belleau.
The reaction is a Grignard reaction, followed by a H-shift and an Aldol addition reaction. The last step is an elimination (Aldol condensation) reaction with an E1CB mechanism.
[edit] References
- George I. Fujimoto (1951). "Labeling of Steroids in the 4-Position". J. Am. Chem. Soc. 73: 1856–1856. doi:.
- Bernard Belleau (1951). "The Reaction of Methylmagnesium Iodide with β-(1-Hydroxy-3,4-dihydro-2-naphthyl)-butyric Acid Lactone". J. Am. Chem. Soc. 73: 5441–5443. doi:.
- Weill-Raynal, J. Synthesis 1969, 49.
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