Fucose-1-phosphate guanylyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) is an enzyme that catalyzes the chemical reaction

GTP + beta-L-fucose 1-phosphate diphosphate + GDP-L-fucose

Thus, the two substrates of this enzyme are GTP and beta-L-fucose 1-phosphate, whereas its two products are diphosphate and GDP-L-fucose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:beta-L-fucose-1-phosphate guanylyltransferase. Other names in common use include GDP fucose pyrophosphorylase, guanosine diphosphate L-fucose pyrophosphorylase, GDP-L-fucose pyrophosphorylase, GDP-fucose pyrophosphorylase, and GTP:L-fucose-1-phosphate guanylyltransferase. This enzyme participates in fructose and mannose metabolism.

[edit] References

• IUBMB entry for 2.7.7.30
• BRENDA references for 2.7.7.30 (Recommended.)
• PubMed references for 2.7.7.30
• PubMed Central references for 2.7.7.30
• Google Scholar references for 2.7.7.30
• Ishihara H, Heath EC (1968). "The metabolism of L-fucose. IV. The biosynthesis of guanosine diphosphate L-fucose in porcine liver". J. Biol. Chem. 243: 1110–5. PMID 5646162. 

[edit] External links

The CAS registry number for this enzyme class is 9033-14-1.

• IUBMB entry for 2.7.7.30

• KEGG entry for 2.7.7.30

• BRENDA entry for 2.7.7.30

• NiceZyme view of 2.7.7.30

• EC2PDB: PDB structures for 2.7.7.30

• PRIAM entry for 2.7.7.30

• PUMA2 entry for 2.7.7.30

• IntEnz: Integrated Enzyme entry for 2.7.7.30

• MetaCyc entry for 2.7.7.30

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047341: fucose-1-phosphate guanylyltransferase

• AMIGO entry for GO code 0047341: fucose-1-phosphate guanylyltransferase