FSTL3

From Wikipedia, the free encyclopedia

Follistatin-like 3 (secreted glycoprotein)

Identifiers

FSTL3; FLRG; FSRP

External IDs

OMIM: 605343 MGI: 1890391 HomoloGene: 4280

Gene ontology
Molecular Function:	• activin inhibitor activity • activin binding
Cellular Component:	• extracellular space
Biological Process:	• negative regulation of BMP signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005860 (mRNA)
NP_005851 (protein)

NM_031380 (mRNA)
NP_113557 (protein)

Location

Chr 19: 0.63 - 0.63 Mb

Chr 10: 79.18 - 79.19 Mb

Pubmed search

[1]

[2]

Follistatin-like 3 (secreted glycoprotein), also known as FSTL3, is a human gene.^[1]

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.^[1]

[edit] References

^ ^a ^b Entrez Gene: FSTL3 follistatin-like 3 (secreted glycoprotein).

[edit] Further reading

Maguer-Satta V, Rimokh R (2005). "FLRG, member of the follistatin family, a new player in hematopoiesis.". Mol. Cell. Endocrinol. 225 (1-2): 109–18. doi:10.1016/j.mce.2004.07.009. PMID 15451575.
Hayette S, Gadoux M, Martel S, et al. (1998). "FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders.". Oncogene 16 (22): 2949–54. doi:10.1038/sj.onc.1201807. PMID 9671416.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Tortoriello DV, Sidis Y, Holtzman DA, et al. (2001). "Human follistatin-related protein: a structural homologue of follistatin with nuclear localization.". Endocrinology 142 (8): 3426–34. PMID 11459787.
Bartholin L, Maguer-Satta V, Hayette S, et al. (2001). "FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins.". Oncogene 20 (39): 5409–19. doi:10.1038/sj.onc.1204720. PMID 11571638.
Bartholin L, Maguer-Satta V, Hayette S, et al. (2002). "Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function.". Oncogene 21 (14): 2227–35. doi:10.1038/sj.onc.1205294. PMID 11948405.
Hill JJ, Davies MV, Pearson AA, et al. (2002). "The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum.". J. Biol. Chem. 277 (43): 40735–41. doi:10.1074/jbc.M206379200. PMID 12194980.
Liu J, Vänttinen T, Hydén-Granskog C, Voutilainen R (2003). "Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E(2) in cultured granulosa-luteal cells.". Mol. Hum. Reprod. 8 (11): 992–7. PMID 12397211.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Maguer-Satta V, Bartholin L, Jeanpierre S, et al. (2003). "Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family.". Exp. Cell Res. 282 (2): 110–20. PMID 12531697.
Wang HQ, Takebayashi K, Tsuchida K, et al. (2003). "Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells.". J. Clin. Endocrinol. Metab. 88 (9): 4432–9. PMID 12970321.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Xia Y, Sidis Y, Schneyer A (2004). "Overexpression of follistatin-like 3 in gonads causes defects in gonadal development and function in transgenic mice.". Mol. Endocrinol. 18 (4): 979–94. doi:10.1210/me.2003-0364. PMID 14739256.
Florio P, Ciarmela P, Toti P, et al. (2004). "Human endometrium and decidua express follistatin-related gene (FLRG) mRNA and peptide.". Mol. Cell. Endocrinol. 218 (1-2): 129–35. doi:10.1016/j.mce.2003.12.019. PMID 15130517.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Glusman G, Kaur A, Hood L, Rowen L (2005). "An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution.". BMC Evol. Biol. 4: 43. doi:10.1186/1471-2148-4-43. PMID 15527507.
Saito S, Sidis Y, Mukherjee A, et al. (2006). "Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3.". Endocrinology 146 (12): 5052–62. doi:10.1210/en.2005-0833. PMID 16150905.
Okamoto A, Endo H, Kalionis B, et al. (2006). "IGFBP1 and Follistatin-like 3 genes are significantly up-regulated in expression profiles of the IUGR placenta.". Placenta 27 (2-3): 317–21. doi:10.1016/j.placenta.2004.12.007. PMID 16338475.