FSTL1

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Follistatin-like 1
Identifiers
Symbol(s) FSTL1; FRP; FSL1
External IDs OMIM: 605547 MGI: 102793 HomoloGene: 5144
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 11167 14314
Ensembl ENSG00000163430 ENSMUSG00000022816
Uniprot Q12841 Q6GTX2
Refseq NM_007085 (mRNA)
NP_009016 (protein)		 NM_008047 (mRNA)
NP_032073 (protein)
Location Chr 3: 121.6 - 121.65 Mb Chr 16: 37.73 - 37.75 Mb
Pubmed search [1] [2]

Follistatin-like 1, also known as FSTL1, is a human gene.[1]

This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis.[1]

[edit] References

  1. ^ a b Entrez Gene: FSTL1 follistatin-like 1.

[edit] Further reading

  • Zwijsen A, Blockx H, Van Arnhem W, et al. (1994). "Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue.". Eur. J. Biochem. 225 (3): 937-46. PMID 7957230. 
  • Tanaka M, Ozaki S, Osakada F, et al. (1998). "Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases.". Int. Immunol. 10 (9): 1305-14. PMID 9786430. 
  • Vertegaal AC, Kuiperij HB, van Laar T, et al. (2001). "cDNA micro array identification of a gene differentially expressed in adenovirus type 5- versus type 12-transformed cells.". FEBS Lett. 487 (2): 151-5. PMID 11150499. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ciarmela P, Florio P, Sigurdardottir M, et al. (2004). "Follistatin-related gene expression, but not follistatin expression, is decreased in human endometrial adenocarcinoma.". Eur. J. Endocrinol. 151 (2): 251-7. PMID 15296481. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ehara Y, Sakurai D, Tsuchiya N, et al. (2005). "Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility.". Clin. Exp. Rheumatol. 22 (6): 707-12. PMID 15638044. 
  • Liu S, Wang L, Wang W, et al. (2006). "TSC-36/FRP inhibits vascular smooth muscle cell proliferation and migration.". Exp. Mol. Pathol. 80 (2): 132-40. doi:10.1016/j.yexmp.2005.07.005. PMID 16256108. 
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070-80. doi:10.1021/pr0502065. PMID 16335952. 
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