FSCN1

From Wikipedia, the free encyclopedia

Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

PDB rendering based on 1dfc.

Available structures: 1dfc

Identifiers

Symbol(s)

FSCN1; p55; FLJ38511; SNL

External IDs

OMIM: 602689 MGI: 1352745 HomoloGene: 48164

Gene ontology
Molecular Function:	• protein binding, bridging • actin filament binding
Cellular Component:	• actin cytoskeleton
Biological Process:	• cell proliferation • actin cytoskeleton organization and biogenesis • actin filament bundle formation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003088 (mRNA)
NP_003079 (protein)

NM_007984 (mRNA)
NP_032010 (protein)

Location

Chr 7: 5.6 - 5.61 Mb

Chr 5: 143.23 - 143.24 Mb

Pubmed search

[1]

[2]

Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus), also known as FSCN1, is a human gene.^[1]

[edit] References

^ Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus).

[edit] Further reading

Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. PMID 1602151.
Yamashiro-Matsumura S, Matsumura F (1985). "Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells.". J. Biol. Chem. 260 (8): 5087–97. PMID 3886649.
Mosialos G, Yamashiro S, Baughman RW, et al. (1994). "Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein.". J. Virol. 68 (11): 7320–8. PMID 7933116.
Duh FM, Latif F, Weng Y, et al. (1994). "cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein.". DNA Cell Biol. 13 (8): 821–7. PMID 8068206.
Mosialos G, Birkenbach M, Ayehunie S, et al. (1996). "Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein.". Am. J. Pathol. 148 (2): 593–600. PMID 8579121.
Yamakita Y, Ono S, Matsumura F, Yamashiro S (1996). "Phosphorylation of human fascin inhibits its actin binding and bundling activities.". J. Biol. Chem. 271 (21): 12632–8. PMID 8647875.
Lin XH, Grako KA, Burg MA, Stallcup WB (1997). "NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration.". Mol. Biol. Cell 7 (12): 1977–93. PMID 8970159.
Ono S, Yamakita Y, Yamashiro S, et al. (1997). "Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin.". J. Biol. Chem. 272 (4): 2527–33. PMID 8999969.
Pinkus GS, Pinkus JL, Langhoff E, et al. (1997). "Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?". Am. J. Pathol. 150 (2): 543–62. PMID 9033270.
Ross R, Ross XL, Schwing J, et al. (1998). "The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells.". J. Immunol. 160 (8): 3776–82. PMID 9558080.
Sonderbye L, Meehan S, Palsson R, et al. (1998). "Immunohistochemical study of actin binding protein (p55) in the human kidney.". Transplantation 65 (7): 1004–8. PMID 9565110.
Tubb BE, Bardien-Kruger S, Kashork CD, et al. (2000). "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes.". Genomics 65 (2): 146–56. doi:10.1006/geno.2000.6156. PMID 10783262.
Kempf W, Levi E, Kamarashev J, et al. (2003). "Fascin expression in CD30-positive cutaneous lymphoproliferative disorders.". J. Cutan. Pathol. 29 (5): 295–300. PMID 12100631.
Goncharuk VN, Ross JS, Carlson JA (2003). "Actin-binding protein fascin expression in skin neoplasia.". J. Cutan. Pathol. 29 (7): 430–8. PMID 12139639.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Pelosi G, Pastorino U, Pasini F, et al. (2003). "Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer.". Br. J. Cancer 88 (4): 537–47. doi:10.1038/sj.bjc.6600731. PMID 12592367.
Shonukan O, Bagayogo I, McCrea P, et al. (2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin.". Oncogene 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270.
Bros M, Ross XL, Pautz A, et al. (2003). "The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer.". J. Immunol. 171 (4): 1825–34. PMID 12902483.
Anilkumar N, Parsons M, Monk R, et al. (2004). "Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility.". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMID 14532112.
Ishikawa R, Sakamoto T, Ando T, et al. (2003). "Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro.". J. Neurochem. 87 (3): 676–85. PMID 14535950.