Fructuronate reductase

From Wikipedia, the free encyclopedia

In enzymology, a fructuronate reductase (EC 1.1.1.57) is an enzyme that catalyzes the chemical reaction

D-mannonate + NAD⁺ D-fructuronate + NADH + H⁺

Thus, the two substrates of this enzyme are D-mannonate and NAD⁺, whereas its 3 products are D-fructuronate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannonate:NAD+ 5-oxidoreductase. Other names in common use include mannonate oxidoreductase, mannonic dehydrogenase, D-mannonate dehydrogenase, and D-mannonate:NAD+ oxidoreductase. This enzyme participates in pentose and glucuronate interconversions.

[edit] References

• IUBMB entry for 1.1.1.57
• BRENDA references for 1.1.1.57 (Recommended.)
• PubMed references for 1.1.1.57
• PubMed Central references for 1.1.1.57
• Google Scholar references for 1.1.1.57
• Hickman J and Ashwell G (1960). "Uronic acid metabolism in bacteria. II. Purification and properties of D-altronic acid and D-mannonic acid dehyrogenases in Escherichia coli". J. Biol. Chem. 235: 1566–1570. 
• KILGORE WW, STARR MP (1959). "Catabolism of galacturonic and glucuronic acids by Erwinia carotovora". J. Biol. Chem. 234: 2227–35. PMID 14409051. 

[edit] External links

The CAS registry number for this enzyme class is 9028-44-8.

• IUBMB entry for 1.1.1.57

• KEGG entry for 1.1.1.57

• BRENDA entry for 1.1.1.57

• NiceZyme view of 1.1.1.57

• EC2PDB: PDB structures for 1.1.1.57

• PRIAM entry for 1.1.1.57

• PUMA2 entry for 1.1.1.57

• IntEnz: Integrated Enzyme entry for 1.1.1.57

• MetaCyc entry for 1.1.1.57

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008866: fructuronate reductase

• AMIGO entry for GO code 0008866: fructuronate reductase