FRS3

From Wikipedia, the free encyclopedia

Fibroblast growth factor receptor substrate 3

Identifiers

FRS3; SNT2; FRS2B; FRS2beta; MGC17167; SNT-2

External IDs

OMIM: 607744 MGI: 2135965 HomoloGene: 4845

Gene ontology
Molecular Function:	• insulin receptor binding
Cellular Component:	• membrane
Biological Process:	• signal transduction • fibroblast growth factor receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006653 (mRNA)
NP_006644 (protein)

NM_144939 (mRNA)
NP_659188 (protein)

Location

Chr 6: 41.85 - 41.86 Mb

Chr 17: 47.16 - 47.17 Mb

Pubmed search

[1]

[2]

Fibroblast growth factor receptor substrate 3, also known as FRS3, is a human gene.^[1]

The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.^[1]

[edit] References

^ ^a ^b Entrez Gene: FRS3 fibroblast growth factor receptor substrate 3.

[edit] Further reading

Wang JK, Xu H, Li HC, Goldfarb M (1996). "Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras.". Oncogene 13 (4): 721-9. PMID 8761293.
Xu H, Lee KW, Goldfarb M (1998). "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins.". J. Biol. Chem. 273 (29): 17987-90. PMID 9660748.
Lim YP, Low BC, Lim J, et al. (1999). "Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling.". J. Biol. Chem. 274 (27): 19025-34. PMID 10383403.
Ong SH, Guy GR, Hadari YR, et al. (2000). "FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.". Mol. Cell. Biol. 20 (3): 979-89. PMID 10629055.
Yamada M, Suzuki K, Mizutani M, et al. (2001). "Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system.". J. Biochem. 130 (1): 157-65. PMID 11432792.
Yan KS, Kuti M, Yan S, et al. (2002). "FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors.". J. Biol. Chem. 277 (19): 17088-94. doi:10.1074/jbc.M107963200. PMID 11877385.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ranzi V, Meakin SO, Miranda C, et al. (2003). "The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins.". Endocrinology 144 (3): 922-8. PMID 12586769.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Gotoh N, Laks S, Nakashima M, et al. (2004). "FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts.". FEBS Lett. 564 (1-2): 14-8. doi:10.1016/S0014-5793(04)00287-X. PMID 15094036.
Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.". Proteomics 4 (5): 1346-58. doi:10.1002/pmic.200300770. PMID 15188402.
Huang L, Gotoh N, Zhang S, et al. (2004). "SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation.". Biochem. Biophys. Res. Commun. 324 (3): 1011-7. doi:10.1016/j.bbrc.2004.09.152. PMID 15485655.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Harada A, Katoh H, Negishi M (2005). "Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells.". J. Biol. Chem. 280 (18): 18418-24. doi:10.1074/jbc.M411356200. PMID 15738000.
Huang L, Watanabe M, Chikamori M, et al. (2006). "Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways.". Oncogene 25 (49): 6457-66. doi:10.1038/sj.onc.1209656. PMID 16702953.