FRK (gene)

From Wikipedia, the free encyclopedia

Fyn-related kinase

Identifiers

FRK; GTK; PTK5; RAK

External IDs

OMIM: 606573 MGI: 103265 HomoloGene: 48065

Gene ontology
Molecular Function:	• nucleotide binding • non-membrane spanning protein tyrosine kinase activity • ATP binding • transferase activity
Cellular Component:	• intracellular • nucleus
Biological Process:	• regulation of progression through cell cycle • protein amino acid phosphorylation • intracellular signaling cascade • negative regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002031 (mRNA)
NP_002022 (protein)

NM_010237 (mRNA)
NP_034367 (protein)

Location

Chr 6: 116.37 - 116.49 Mb

Chr 10: 34.17 - 34.3 Mb

Pubmed search

[1]

[2]

Fyn-related kinase, also known as FRK, is a human gene.^[1]

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.^[1]

[edit] References

^ ^a ^b Entrez Gene: FRK fyn-related kinase.

[edit] Further reading

Serfas MS, Tyner AL (2003). "Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.". Oncol. Res. 13 (6-10): 409-19. PMID 12725532.
Lee J, Wang Z, Luoh SM, et al. (1994). "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene.". Gene 138 (1-2): 247-51. PMID 7510261.
Craven RJ, Cance WG, Liu ET (1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb.". Cancer Res. 55 (18): 3969-72. PMID 7664264.
Cance WG, Craven RJ, Bergman M, et al. (1995). "Rak, a novel nuclear tyrosine kinase expressed in epithelial cells.". Cell Growth Differ. 5 (12): 1347-55. PMID 7696183.
Cance WG, Craven RJ, Weiner TM, Liu ET (1993). "Novel protein kinases expressed in human breast cancer.". Int. J. Cancer 54 (4): 571-7. PMID 8099900.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Meyer T, Xu L, Chang J, et al. (2003). "Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase.". Int. J. Cancer 104 (2): 139-46. doi:10.1002/ijc.10925. PMID 12569567.
Watanabe T, Ohnuma T, Shibata N, et al. (2004). "No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease.". Neurosci. Lett. 360 (1-2): 109-11. doi:10.1016/j.neulet.2004.02.046. PMID 15082191.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240-50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.