FRAT2

From Wikipedia, the free encyclopedia

Frequently rearranged in advanced T-cell lymphomas 2

Identifiers

FRAT2; MGC10562

External IDs

OMIM: 605006 MGI: 2673967 HomoloGene: 8095

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• cellular_component
Biological Process:	• multicellular organismal development • cell proliferation • Wnt receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012083 (mRNA)
NP_036215 (protein)

XM_977206 (mRNA)
XP_982300 (protein)

Location

Chr 10: 99.08 - 99.08 Mb

Chr 19: 41.9 - 41.9 Mb

Pubmed search

[1]

[2]

Frequently rearranged in advanced T-cell lymphomas 2, also known as FRAT2, is a human gene.^[1]

The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.^[1]

[edit] References

^ ^a ^b Entrez Gene: FRAT2 frequently rearranged in advanced T-cell lymphomas 2.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Yost C, Farr GH, Pierce SB, et al. (1998). "GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis.". Cell 93 (6): 1031-41. PMID 9635432.
Saitoh T, Moriwaki J, Koike J, et al. (2001). "Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway.". Biochem. Biophys. Res. Commun. 281 (3): 815-20. doi:10.1006/bbrc.2001.4421. PMID 11237732.
Bax B, Carter PS, Lewis C, et al. (2002). "The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.". Structure 9 (12): 1143-52. PMID 11738041.
Freemantle SJ, Portland HB, Ewings K, et al. (2002). "Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2.". Gene 291 (1-2): 17-27. PMID 12095675.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Stoothoff WH, Cho JH, McDonald RP, Johnson GV (2005). "FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation.". J. Biol. Chem. 280 (1): 270-6. doi:10.1074/jbc.M410061200. PMID 15522877.