FPGT

From Wikipedia, the free encyclopedia

Fucose-1-phosphate guanylyltransferase

Identifiers

FPGT; GFPP

External IDs

OMIM: 603609 MGI: 1922790 HomoloGene: 2847

Gene ontology
Molecular Function:	• transferase activity • fucose-1-phosphate guanylyltransferase activity
Cellular Component:	• cytoplasm
Biological Process:	• fucose metabolic process

Orthologs

Human

Mouse

n/a

Refseq

NM_003838 (mRNA)
NP_003829 (protein)

XM_001005515 (mRNA)
XP_001005515 (protein)

Location

n/a

Chr 3: 155.02 - 155.03 Mb

Pubmed search

[1]

[2]

Fucose-1-phosphate guanylyltransferase, also known as FPGT, is a human gene.^[1]

L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose.^[1]

[edit] References

^ ^a ^b Entrez Gene: FPGT fucose-1-phosphate guanylyltransferase.

[edit] Further reading

Quirk S, Seley-Radtke KL (2006). "Purification, crystallization and preliminary X-ray characterization of the human GTP fucose pyrophosphorylase.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 (Pt 4): 392-4. doi:10.1107/S1744309106008529. PMID 16582493.
Quirk S, Seley KL (2005). "Identification of catalytic amino acids in the human GTP fucose pyrophosphorylase active site.". Biochemistry 44 (39): 13172-8. doi:10.1021/bi051288d. PMID 16185085.
Quirk S, Seley KL (2005). "Substrate discrimination by the human GTP fucose pyrophosphorylase.". Biochemistry 44 (32): 10854-63. doi:10.1021/bi0503605. PMID 16086588.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Pastuszak I, Ketchum C, Hermanson G, et al. (1998). "GDP-L-fucose pyrophosphorylase. Purification, cDNA cloning, and properties of the enzyme.". J. Biol. Chem. 273 (46): 30165-74. PMID 9804772.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.