FOXP4

From Wikipedia, the free encyclopedia

Forkhead box P4

Identifiers

FOXP4; FLJ40908; hFKHLA

External IDs

OMIM: 608924 MGI: 1921373 HomoloGene: 12536

Gene ontology
Molecular Function:	• nucleic acid binding • transcription factor activity • zinc ion binding • transcription repressor activity • protein homodimerization activity • sequence-specific DNA binding • metal ion binding • protein heterodimerization activity
Cellular Component:	• intracellular • nucleus
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • transcription • regulation of transcription, DNA-dependent • heart development • embryonic foregut morphogenesis

Orthologs

Human

Mouse

Refseq

NM_001012426 (mRNA)
NP_001012426 (protein)

NM_028767 (mRNA)
NP_083043 (protein)

Location

Chr 6: 41.62 - 41.68 Mb

Chr 17: 47.33 - 47.39 Mb

Pubmed search

[1]

[2]

Forkhead box P4, also known as FOXP4, is a human gene.^[1]

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: FOXP4 forkhead box P4.

[edit] Further reading

Katoh M, Katoh M (2005). "Human FOX gene family (Review).". Int. J. Oncol. 25 (5): 1495-500. PMID 15492844.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lu MM, Li S, Yang H, Morrisey EE (2003). "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues.". Gene Expr. Patterns 2 (3-4): 223-8. PMID 12617805.
Teufel A, Wong EA, Mukhopadhyay M, et al. (2003). "FoxP4, a novel forkhead transcription factor.". Biochim. Biophys. Acta 1627 (2-3): 147-52. PMID 12818433.
Lu MM, Li S, Yang H, Morrisey EE. "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues.". Mech. Dev. 119 Suppl 1: S197-202. PMID 14516685.
Li S, Weidenfeld J, Morrisey EE (2004). "Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions.". Mol. Cell. Biol. 24 (2): 809-22. PMID 14701752.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hannenhalli S, Putt ME, Gilmore JM, et al. (2006). "Transcriptional genomics associates FOX transcription factors with human heart failure.". Circulation 114 (12): 1269-76. doi:10.1161/CIRCULATIONAHA.106.632430. PMID 16952980.