FOXO1A

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Forkhead box O1A (rhabdomyosarcoma)
Identifiers
Symbol(s) FOXO1A; FKH1; FKHR; FOXO1
External IDs OMIM: 136533 MGI: 1890077 HomoloGene: 1527
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2308 56458
Ensembl ENSG00000150907 ENSMUSG00000044167
Uniprot Q12778 Q8BPP2
Refseq NM_002015 (mRNA)
NP_002006 (protein)		 NM_019739 (mRNA)
NP_062713 (protein)
Location Chr 13: 40.03 - 40.14 Mb Chr 3: 52.36 - 52.44 Mb
Pubmed search [1] [2]

Forkhead box O1A (rhabdomyosarcoma), also known as FOXO1A, is a human gene.

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.[1]

[edit] References

  1. ^ Entrez Gene: FOXO1A forkhead box O1A (rhabdomyosarcoma).

[edit] Further reading

  • Sublett JE, Jeon IS, Shapiro DN (1995). "The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator.". Oncogene 11 (3): 545–52. PMID 7630639. 
  • Fredericks WJ, Galili N, Mukhopadhyay S, et al. (1995). "The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3.". Mol. Cell. Biol. 15 (3): 1522–35. PMID 7862145. 
  • Galili N, Davis RJ, Fredericks WJ, et al. (1994). "Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.". Nat. Genet. 5 (3): 230–5. doi:10.1038/ng1193-230. PMID 8275086. 
  • Scheidler S, Fredericks WJ, Rauscher FJ, et al. (1996). "The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture.". Proc. Natl. Acad. Sci. U.S.A. 93 (18): 9805–9. PMID 8790412. 
  • Anderson MJ, Viars CS, Czekay S, et al. (1998). "Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.". Genomics 47 (2): 187–99. doi:10.1006/geno.1997.5122. PMID 9479491. 
  • Tang ED, Nuñez G, Barr FG, Guan KL (1999). "Negative regulation of the forkhead transcription factor FKHR by Akt.". J. Biol. Chem. 274 (24): 16741–6. PMID 10358014. 
  • Rena G, Guo S, Cichy SC, et al. (1999). "Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.". J. Biol. Chem. 274 (24): 17179–83. PMID 10358075. 
  • Medema RH, Kops GJ, Bos JL, Burgering BM (2000). "AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.". Nature 404 (6779): 782–7. doi:10.1038/35008115. PMID 10783894. 
  • Margue CM, Bernasconi M, Barr FG, Schäfer BW (2000). "Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR.". Oncogene 19 (25): 2921–9. doi:10.1038/sj.onc.1203607. PMID 10871843. 
  • Nasrin N, Ogg S, Cahill CM, et al. (2000). "DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10412–7. doi:10.1073/pnas.190326997. PMID 10973497. 
  • Jackson JG, Kreisberg JI, Koterba AP, et al. (2000). "Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.". Oncogene 19 (40): 4574–81. doi:10.1038/sj.onc.1203825. PMID 11030146. 
  • Rena G, Prescott AR, Guo S, et al. (2001). "Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.". Biochem. J. 354 (Pt 3): 605–12. PMID 11237865. 
  • Woods YL, Rena G, Morrice N, et al. (2001). "The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.". Biochem. J. 355 (Pt 3): 597–607. PMID 11311120. 
  • Zhao HH, Herrera RE, Coronado-Heinsohn E, et al. (2001). "Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions.". J. Biol. Chem. 276 (30): 27907–12. doi:10.1074/jbc.M104278200. PMID 11353774. 
  • Schuur ER, Loktev AV, Sharma M, et al. (2001). "Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family.". J. Biol. Chem. 276 (36): 33554–60. doi:10.1074/jbc.M105555200. PMID 11435445. 
  • Patel S, Lochhead PA, Rena G, Sutherland C (2001). "Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression.". Biochem. J. 359 (Pt 3): 611–9. PMID 11672436. 
  • Ayalon D, Glaser T, Werner H (2002). "Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein.". Growth Horm. IGF Res. 11 (5): 289–97. doi:10.1054/ghir.2001.0244. PMID 11735247. 
  • Christian M, Zhang X, Schneider-Merck T, et al. (2002). "Cyclic AMP-induced forkhead transcription factor, FKHR, cooperates with CCAAT/enhancer-binding protein beta in differentiating human endometrial stromal cells.". J. Biol. Chem. 277 (23): 20825–32. doi:10.1074/jbc.M201018200. PMID 11893744. 
  • Rena G, Woods YL, Prescott AR, et al. (2002). "Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.". EMBO J. 21 (9): 2263–71. doi:10.1093/emboj/21.9.2263. PMID 11980723. 
  • Sorensen PH, Lynch JC, Qualman SJ, et al. (2002). "PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group.". J. Clin. Oncol. 20 (11): 2672–9. PMID 12039929. 

[edit] External links


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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD