FOXH1

From Wikipedia, the free encyclopedia


Forkhead box H1
Identifiers
Symbol(s) FOXH1; FAST-1; FAST1
External IDs OMIM: 603621 MGI: 1347465 HomoloGene: 2914
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8928 14106
Ensembl ENSG00000160973 ENSMUSG00000033837
Uniprot O75593 Q0VEP8
Refseq NM_003923 (mRNA)
NP_003914 (protein)		 NM_007989 (mRNA)
NP_032015 (protein)
Location Chr 8: 145.67 - 145.67 Mb Chr 15: 76.5 - 76.5 Mb
Pubmed search [1] [2]

Forkhead box H1, also known as FOXH1, is a human gene.[1]

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: FOXH1 forkhead box H1.

[edit] Further reading

  • Chen X, Weisberg E, Fridmacher V, et al. (1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor.". Nature 389 (6646): 85-9. doi:10.1038/38008. PMID 9288972. 
  • Liu F, Pouponnot C, Massagué J (1998). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.". Genes Dev. 11 (23): 3157-67. PMID 9389648. 
  • Zhou S, Zawel L, Lengauer C, et al. (1998). "Characterization of human FAST-1, a TGF beta and activin signal transducer.". Mol. Cell 2 (1): 121-7. PMID 9702198. 
  • Liu B, Dou CL, Prabhu L, Lai E (1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals.". Mol. Cell. Biol. 19 (1): 424-30. PMID 9858566. 
  • Dou C, Lee J, Liu B, et al. (2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners.". Mol. Cell. Biol. 20 (17): 6201-11. PMID 10938097. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Pessah M, Prunier C, Marais J, et al. (2001). "c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity.". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6198-203. doi:10.1073/pnas.101579798. PMID 11371641. 
  • Iratni R, Yan YT, Chen C, et al. (2003). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1.". Science 298 (5600): 1996-9. doi:10.1126/science.1073405. PMID 12471260. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Seoane J, Le HV, Shen L, et al. (2004). "Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.". Cell 117 (2): 211-23. PMID 15084259. 
  • von Both I, Silvestri C, Erdemir T, et al. (2004). "Foxh1 is essential for development of the anterior heart field.". Dev. Cell 7 (3): 331-45. doi:10.1016/j.devcel.2004.07.023. PMID 15363409. 
  • Kelemen SF, Eisen HJ, Autieri MV (2005). "Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle cells.". J. Heart Lung Transplant. 24 (3): 246-50. doi:10.1016/j.healun.2004.01.015. PMID 15737749. 
  • Cui Q, Lim SK, Zhao B, Hoffmann FM (2005). "Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP.". Oncogene 24 (24): 3864-74. doi:10.1038/sj.onc.1208556. PMID 15750622. 
  • Hart AH, Willson TA, Wong M, et al. (2005). "Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1.". Biochem. Biophys. Res. Commun. 333 (4): 1361-9. doi:10.1016/j.bbrc.2005.06.044. PMID 15982639. 
  • Chen G, Nomura M, Morinaga H, et al. (2006). "Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor.". J. Biol. Chem. 280 (43): 36355-63. doi:10.1074/jbc.M506147200. PMID 16120611. 

[edit] External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD