Formyltetrahydrofolate dehydrogenase
From Wikipedia, the free encyclopedia
In enzymology, a formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) is an enzyme that catalyzes the chemical reaction
- 10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
The 3 substrates of this enzyme are 10-formyltetrahydrofolate, NADP+, and H2O, whereas its 4 products are tetrahydrofolate, CO2, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 10-formyltetrahydrofolate:NADP+ oxidoreductase. Other names in common use include 10-formyl tetrahydrofolate:NADP oxidoreductase, 10-formyl-H2PtGlu:NADP oxidoreductase, 10-formyl-H4folate dehydrogenase, N10-formyltetrahydrofolate dehydrogenase, and 10-formyltetrahydrofolate dehydrogenase. This enzyme participates in one carbon pool by folate.
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[edit] Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1S3I, 2BW0, 2CFI, 2CQ8, 2O2P, 2O2Q, and 2O2R.
[edit] References
- IUBMB entry for 1.5.1.6
- BRENDA references for 1.5.1.6 (Recommended.)
- PubMed references for 1.5.1.6
- PubMed Central references for 1.5.1.6
- Google Scholar references for 1.5.1.6
- Kutzbach C, Stokstad EL (1968). "Partial purification of a 10-formyl-tetrahydrofolate: NADP oxidoreductase from mammalian liver". Biochem. Biophys. Res. Commun. 30: 111–7. doi:. PMID 4384443.
[edit] External links
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- The CAS registry number for this enzyme class is 37256-25-0.
[edit] Gene Ontology (GO) codes
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