Formyltetrahydrofolate deformylase

From Wikipedia, the free encyclopedia

In enzymology, a formyltetrahydrofolate deformylase (EC 3.5.1.10) is an enzyme that catalyzes the chemical reaction

10-formyltetrahydrofolate + H₂O formate + tetrahydrofolate

Thus, the two substrates of this enzyme are 10-formyltetrahydrofolate and H₂O, whereas its two products are formate and tetrahydrofolate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 10-formyltetrahydrofolate amidohydrolase. This enzyme participates in glyoxylate and dicarboxylate metabolism and one carbon pool by folate.

[edit] References

• IUBMB entry for 3.5.1.10
• BRENDA references for 3.5.1.10 (Recommended.)
• PubMed references for 3.5.1.10
• PubMed Central references for 3.5.1.10
• Google Scholar references for 3.5.1.10
• Huennekens FM (1957). "Enzymatic deacylation of N10-formyltetrahydrofolic acid". Fed. Proc. 16: 199. 

[edit] External links

The CAS registry number for this enzyme class is 9025-08-5.

• IUBMB entry for 3.5.1.10

• KEGG entry for 3.5.1.10

• BRENDA entry for 3.5.1.10

• NiceZyme view of 3.5.1.10

• EC2PDB: PDB structures for 3.5.1.10

• PRIAM entry for 3.5.1.10

• PUMA2 entry for 3.5.1.10

• IntEnz: Integrated Enzyme entry for 3.5.1.10

• MetaCyc entry for 3.5.1.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008864: formyltetrahydrofolate deformylase

• AMIGO entry for GO code 0008864: formyltetrahydrofolate deformylase