Formylmethionine deformylase

From Wikipedia, the free encyclopedia

In enzymology, a formylmethionine deformylase (EC 3.5.1.31) is an enzyme that catalyzes the chemical reaction

N-formyl-L-methionine + H₂O formate + L-methionine

Thus, the two substrates of this enzyme are N-formyl-L-methionine and H₂O, whereas its two products are formate and L-methionine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-formyl-L-methionine amidohydrolase. This enzyme participates in methionine metabolism and glyoxylate and dicarboxylate metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 1BS4, 1BS5, 1BS6, 1BS7, 1BS8, 1BSZ, 1DEF, 1DFF, 1G27, 1G2A, 1ICJ, 1JYM, 1RL4, and 2DEF.

[edit] References

• IUBMB entry for 3.5.1.31
• BRENDA references for 3.5.1.31 (Recommended.)
• PubMed references for 3.5.1.31
• PubMed Central references for 3.5.1.31
• Google Scholar references for 3.5.1.31
• Aronson JN, Lugay JC (1969). "N-Formylmethionine deformylase from Euglena gracilis". Biochem. Biophys. Res. Commun. 34: 311–4. doi:10.1016/0006-291X(69)90833-X. PMID 5767026. 

[edit] External links

The CAS registry number for this enzyme class is 9032-86-4.

• IUBMB entry for 3.5.1.31

• KEGG entry for 3.5.1.31

• BRENDA entry for 3.5.1.31

• NiceZyme view of 3.5.1.31

• EC2PDB: PDB structures for 3.5.1.31

• PRIAM entry for 3.5.1.31

• PUMA2 entry for 3.5.1.31

• IntEnz: Integrated Enzyme entry for 3.5.1.31

• MetaCyc entry for 3.5.1.31

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008463: formylmethionine deformylase

• AMIGO entry for GO code 0008463: formylmethionine deformylase