Formylmethanofuran-tetrahydromethanopterin N-formyltransferase

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In enzymology, a formylmethanofuran-tetrahydromethanopterin N-formyltransferase (EC 2.3.1.101) is an enzyme that catalyzes the chemical reaction

formylmethanofuran + 5,6,7,8-tetrahydromethanopterin $\rightleftharpoons$ methanofuran + 5-formyl-5,6,7,8-tetrahydromethanopterin

Thus, the two substrates of this enzyme are formylmethanofuran and 5,6,7,8-tetrahydromethanopterin, whereas its two products are methanofuran and 5-formyl-5,6,7,8-tetrahydromethanopterin.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase. Other names in common use include formylmethanofuran-tetrahydromethanopterin formyltransferase, formylmethanofuran:tetrahydromethanopterin formyltransferase, N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT), formyltransferase, FTR, formylmethanofuran:5,6,7,8-tetrahydromethanopterin, and N5-formyltransferase. This enzyme participates in folate biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1FTR, 1M5H, 1M5S, 2FHJ, and 2FHK.

[edit] References

IUBMB entry for 2.3.1.101
BRENDA references for 2.3.1.101 (Recommended.)
PubMed references for 2.3.1.101
PubMed Central references for 2.3.1.101
Google Scholar references for 2.3.1.101
Donnelly MI, Wolfe RS (1986). "The role of formylmethanofuran: tetrahydromethanopterin formyltransferase in methanogenesis from carbon dioxide". J. Biol. Chem. 261: 16653–9. PMID 3097011.
Leigh JA, Rinehart KL and Wolfe RS (1984). "Structure of methanofuran, the carbon-dioxide reduction factor of Methanobacterium thermoautotrophicum". J. Am. Chem. Soc. 106: 3636–3640.