Formimidoylglutamase

From Wikipedia, the free encyclopedia

In enzymology, a formimidoylglutamase (EC 3.5.3.8) is an enzyme that catalyzes the chemical reaction

N-formimidoyl-L-glutamate + H₂O $\rightleftharpoons$ L-glutamate + formamide

Thus, the two substrates of this enzyme are N-formimidoyl-L-glutamate and H₂O, whereas its two products are L-glutamate and formamide.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is N-formimidoyl-L-glutamate formimidoylhydrolase. Other names in common use include formiminoglutamase, N-formiminoglutamate hydrolase, and N-formimino-L-glutamate formiminohydrolase. This enzyme participates in histidine metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1XFK and 2A0M.

[edit] References

IUBMB entry for 3.5.3.8
BRENDA references for 3.5.3.8 (Recommended.)
PubMed references for 3.5.3.8
PubMed Central references for 3.5.3.8
Google Scholar references for 3.5.3.8
Kaminskas E, Kimhi Y, Magasanik B (1970). "Urocanase and N-formimino-L-glutamate formiminohydrolase of Bacillus subtilis, two enzymes of the histidine degradation pathway". J. Biol. Chem. 245: 3536–44. PMID 4990470.
Lund P, Magasanik B (1965). "N-formimino-L-glutamate formiminohydrolase of Aerobacter aerogenes". J. Biol. Chem. 240: 4316–9. PMID 5845833.