Formimidoylaspartate deiminase

From Wikipedia, the free encyclopedia

In enzymology, a formimidoylaspartate deiminase (EC 3.5.3.5) is an enzyme that catalyzes the chemical reaction

N-formimidoyl-L-aspartate + H₂O N-formyl-L-aspartate + NH₃

Thus, the two substrates of this enzyme are N-formimidoyl-L-aspartate and H₂O, whereas its two products are N-formyl-L-aspartate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is N-formimidoyl-L-aspartate iminohydrolase. This enzyme is also called formiminoaspartate deiminase. This enzyme participates in histidine metabolism.

[edit] References

• IUBMB entry for 3.5.3.5
• BRENDA references for 3.5.3.5 (Recommended.)
• PubMed references for 3.5.3.5
• PubMed Central references for 3.5.3.5
• Google Scholar references for 3.5.3.5
• HAYAISHI O, TABOR H, HAYAISHI T (1957). "N-formimino-L-aspartic acid as an intermediate in the enzymatic conversion of imidazoleacetic acid to formylaspartic acid". J. Biol. Chem. 227: 161–80. PMID 13449062. 

[edit] External links

The CAS registry number for this enzyme class is 9025-07-4.

• IUBMB entry for 3.5.3.5

• KEGG entry for 3.5.3.5

• BRENDA entry for 3.5.3.5

• NiceZyme view of 3.5.3.5

• EC2PDB: PDB structures for 3.5.3.5

• PRIAM entry for 3.5.3.5

• PUMA2 entry for 3.5.3.5

• IntEnz: Integrated Enzyme entry for 3.5.3.5

• MetaCyc entry for 3.5.3.5

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050414: formimidoylaspartate deiminase

• AMIGO entry for GO code 0050414: formimidoylaspartate deiminase