Formate dehydrogenase (cytochrome)

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In enzymology, a formate dehydrogenase (cytochrome) (EC 1.2.2.1) is an enzyme that catalyzes the chemical reaction

formate + 2 ferricytochrome b₁ CO₂ + 2 ferrocytochrome b₁ + 2 H⁺

Thus, the two substrates of this enzyme are formate and ferricytochrome b1, whereas its 3 products are CO₂, ferrocytochrome b1, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with a cytochrome as acceptor. The systematic name of this enzyme class is formate:ferricytochrome-b1 oxidoreductase. Other names in common use include formate dehydrogenase, and formate:cytochrome b1 oxidoreductase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

[edit] References

• IUBMB entry for 1.2.2.1
• BRENDA references for 1.2.2.1 (Recommended.)
• PubMed references for 1.2.2.1
• PubMed Central references for 1.2.2.1
• Google Scholar references for 1.2.2.1
• Gale EF (1939). "Formic dehydrogenase of Bacterium coli: its inactivation by oxygen and its protection in the bacterial cell". Biochem. J. 33: 1012–1027. 

[edit] External links

• IUBMB entry for 1.2.2.1

• KEGG entry for 1.2.2.1

• BRENDA entry for 1.2.2.1

• NiceZyme view of 1.2.2.1

• EC2PDB: PDB structures for 1.2.2.1

• PRIAM entry for 1.2.2.1

• PUMA2 entry for 1.2.2.1

• IntEnz: Integrated Enzyme entry for 1.2.2.1

• MetaCyc entry for 1.2.2.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047898: formate dehydrogenase (cytochrome)

• AMIGO entry for GO code 0047898: formate dehydrogenase (cytochrome)