Formate dehydrogenase (NADP+)

From Wikipedia, the free encyclopedia

In enzymology, a formate dehydrogenase (NADP+) (EC 1.2.1.43) is an enzyme that catalyzes the chemical reaction

formate + NADP⁺ CO₂ + NADPH

Thus, the two substrates of this enzyme are formate and NADP⁺, whereas its two products are CO₂ and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is formate:NADP+ oxidoreductase. Other names in common use include NADP+-dependent formate dehydrogenase, and formate dehydrogenase (NADP+). This enzyme participates in methane metabolism. It has 3 cofactors: iron, Tungsten, and Selenium.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GSD.

[edit] References

• IUBMB entry for 1.2.1.43
• BRENDA references for 1.2.1.43 (Recommended.)
• PubMed references for 1.2.1.43
• PubMed Central references for 1.2.1.43
• Google Scholar references for 1.2.1.43
• Andreesen JR, Ljungdahl LG (1974). "Nicotinamide adenine dinucleotide phosphate-dependent formate dehydrogenase from Clostridium thermoaceticum: purification and properties". J. Bacteriol. 120: 6–14. PMID 4154039. 
• Yamamoto I, Saiki T, Liu SM, Ljungdahl LG (1983). "Purification and properties of NADP-dependent formate dehydrogenase from Clostridium thermoaceticum, a tungsten-selenium-iron protein". J. Biol. Chem. 258: 1826–32. PMID 6822536. 

[edit] External links

The CAS registry number for this enzyme class is 51377-43-6.

• IUBMB entry for 1.2.1.43

• KEGG entry for 1.2.1.43

• BRENDA entry for 1.2.1.43

• NiceZyme view of 1.2.1.43

• EC2PDB: PDB structures for 1.2.1.43

• PRIAM entry for 1.2.1.43

• PUMA2 entry for 1.2.1.43

• IntEnz: Integrated Enzyme entry for 1.2.1.43

• MetaCyc entry for 1.2.1.43

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047899: formate dehydrogenase (NADP+)

• AMIGO entry for GO code 0047899: formate dehydrogenase (NADP+)