Formate C-acetyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a formate C-acetyltransferase (EC 2.3.1.54) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + formate CoA + pyruvate

Thus, the two substrates of this enzyme are acetyl-CoA and formate, whereas its two products are CoA and pyruvate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:formate C-acetyltransferase. Other names in common use include pyruvate formate-lyase, pyruvic formate-lyase, and formate acetyltransferase. This enzyme participates in 3 metabolic pathways: pyruvate metabolism, propanoate metabolism, and butanoate metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1CM5, 1H16, 1H17, 1H18, 1MZO, 1QHM, 2PFL, and 3PFL.

[edit] References

• IUBMB entry for 2.3.1.54
• BRENDA references for 2.3.1.54 (Recommended.)
• PubMed references for 2.3.1.54
• PubMed Central references for 2.3.1.54
• Google Scholar references for 2.3.1.54
• Knappe J, Blaschkowski HP, Grobner P, Schmitt T (1974). "Pyruvate formate-lyase of Escherichia coli: the acetyl-enzyme intermediate". Eur. J. Biochem. 50: 253–63. PMID 4615902. 

[edit] External links

The CAS registry number for this enzyme class is 9068-08-0.

• IUBMB entry for 2.3.1.54

• KEGG entry for 2.3.1.54

• BRENDA entry for 2.3.1.54

• NiceZyme view of 2.3.1.54

• EC2PDB: PDB structures for 2.3.1.54

• PRIAM entry for 2.3.1.54

• PUMA2 entry for 2.3.1.54

• IntEnz: Integrated Enzyme entry for 2.3.1.54

• MetaCyc entry for 2.3.1.54

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008861: formate C-acetyltransferase

• AMIGO entry for GO code 0008861: formate C-acetyltransferase