Formate-dihydrofolate ligase

From Wikipedia, the free encyclopedia

In enzymology, a formate-dihydrofolate ligase (EC 6.3.4.17) is an enzyme that catalyzes the chemical reaction

ATP + formate + dihydrofolate ADP + phosphate + 10-formyldihydrofolate

The 3 substrates of this enzyme are ATP, formate, and dihydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyldihydrofolate.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is formate:dihydrofolate ligase (ADP-forming). Other names in common use include formyltransferase, dihydrofolate, dihydrofolate formyltransferase, and formyl dihydrofolate synthase.

[edit] References

• IUBMB entry for 6.3.4.17
• BRENDA references for 6.3.4.17 (Recommended.)
• PubMed references for 6.3.4.17
• PubMed Central references for 6.3.4.17
• Google Scholar references for 6.3.4.17
• Drake JC, Baram J, Allegra CJ (1990). "Isolation and characterization of a novel dihydrofolate formylating enzyme from human MCF-7 breast cancer cells". Biochem. Pharmacol. 39: 615–8. doi:10.1016/0006-2952(90)90073-T. PMID 2306274. 

[edit] External links

The CAS registry number for this enzyme class is 123303-25-3.

• IUBMB entry for 6.3.4.17

• KEGG entry for 6.3.4.17

• BRENDA entry for 6.3.4.17

• NiceZyme view of 6.3.4.17

• EC2PDB: PDB structures for 6.3.4.17

• PRIAM entry for 6.3.4.17

• PUMA2 entry for 6.3.4.17

• IntEnz: Integrated Enzyme entry for 6.3.4.17

• MetaCyc entry for 6.3.4.17

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047897: formate-dihydrofolate ligase

• AMIGO entry for GO code 0047897: formate-dihydrofolate ligase