Formamidase

From Wikipedia, the free encyclopedia

In enzymology, a formamidase (EC 3.5.1.49) is an enzyme that catalyzes the chemical reaction

formamide + H₂O $\rightleftharpoons$ formate + NH₃

Thus, the two substrates of this enzyme are formamide and H₂O, whereas its two products are formate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is formamide amidohydrolase. This enzyme participates in glyoxylate and dicarboxylate metabolism and nitrogen metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2DYU, 2DYV, 2E2K, and 2E2L.

[edit] References

IUBMB entry for 3.5.1.49
BRENDA references for 3.5.1.49 (Recommended.)
PubMed references for 3.5.1.49
PubMed Central references for 3.5.1.49
Google Scholar references for 3.5.1.49
Clarke PH (1970). "The aliphatic amidases of Pseudomonas aeruginosa". Adv. Microb. Physiol. 4: 179–222.
Friedich CG and Mitrenga G (1981). "Utilization of aliphatic amides and formation of two different amidases by Alcaligenes eutrophus". J. Gen. Microbiol. 125: 367–374.