Formaldehyde dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a formaldehyde dehydrogenase (EC 1.2.1.46) is an enzyme that catalyzes the chemical reaction

formaldehyde + NAD⁺ + H₂O formate + NADH + 2 H⁺

The 3 substrates of this enzyme are formaldehyde, NAD⁺, and H₂O, whereas its 3 products are formate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is formaldehyde:NAD+ oxidoreductase. Other names in common use include NAD+-linked formaldehyde dehydrogenase, and NAD+-dependent formaldehyde dehydrogenase. This enzyme participates in methane metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1KOL.

[edit] References

• IUBMB entry for 1.2.1.46
• BRENDA references for 1.2.1.46 (Recommended.)
• PubMed references for 1.2.1.46
• PubMed Central references for 1.2.1.46
• Google Scholar references for 1.2.1.46
• Hohnloser W, Osswald B, Lingens F (1980). "Enzymological aspects of caffeine demethylation and formaldehyde oxidation by Pseudomonas putida C1". Hoppe. Seylers. Z. Physiol. Chem. 361: 1763–6. PMID 7461603. 

[edit] External links

The CAS registry number for this enzyme class is 9028-84-6.

• IUBMB entry for 1.2.1.46

• KEGG entry for 1.2.1.46

• BRENDA entry for 1.2.1.46

• NiceZyme view of 1.2.1.46

• EC2PDB: PDB structures for 1.2.1.46

• PRIAM entry for 1.2.1.46

• PUMA2 entry for 1.2.1.46

• IntEnz: Integrated Enzyme entry for 1.2.1.46

• MetaCyc entry for 1.2.1.46

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018467: formaldehyde dehydrogenase

• AMIGO entry for GO code 0018467: formaldehyde dehydrogenase