Foreign body response

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The foreign-body response is a reaction of biological tissue to any foreign material in the tissue. Tissue-encapsulation of an implant is part of this. An infection around a splinter is part of this, too.[1]

The presence of the implant changes the healing response, and this is called the foreign-body reaction (FBR). FBR consits of: protein adsorption, macrophages, multinucleated foreign body giant cells (macrophage fusion), fibroblasts, and angiogenesis.

It can be caused by beryllium.[2]

[edit] References

  1. ^ Biomaterials Science Second edition, Ratner et al. Pp. 296-304
  2. ^ Haley PJ (1991). "Mechanisms of granulomatous lung disease from inhaled beryllium: the role of antigenicity in granuloma formation". Toxicologic pathology 19 (4 Pt 1): 514–25. PMID 1813991. 
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