FNTB

From Wikipedia, the free encyclopedia

Farnesyltransferase, CAAX box, beta

PDB rendering based on 1d8d.

Available structures: 1d8d, 1d8e, 1fpp, 1ft1, 1ft2, 1jcq, 1jcr, 1jcs, 1kzo, 1kzp, 1ld7, 1ld8, 1mzc, 1n94, 1n95, 1n9a, 1ni1, 1nl4, 1o1r, 1o1s, 1o1t, 1o5m, 1qbq, 1s63, 1sa4, 1sa5, 1tn6, 1tn7, 1tn8, 1x81, 2bed, 2f0y, 2h6f, 2h6g, 2h6h, 2h6i, 2iej

Identifiers

Symbol(s)

FNTB; FPTB; MGC31935

External IDs

OMIM: 134636 MGI: 1861305 HomoloGene: 1535

Gene ontology
Molecular Function:	• farnesyltranstransferase activity • protein farnesyltransferase activity • protein binding • zinc ion binding • transferase activity • metal ion binding
Cellular Component:	• cytoplasm
Biological Process:	• negative regulation of cell proliferation • protein amino acid farnesylation • wound healing • positive regulation of fibroblast proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002028 (mRNA)
NP_002019 (protein)

XM_989503 (mRNA)
XP_994597 (protein)

Location

Chr 14: 64.52 - 64.6 Mb

n/a

Pubmed search

[1]

[2]

Farnesyltransferase, CAAX box, beta, also known as FNTB, is a human gene.^[1]

[edit] References

^ Entrez Gene: FNTB farnesyltransferase, CAAX box, beta.

[edit] Further reading

Manne V, Roberts D, Tobin A, et al. (1990). "Identification and preliminary characterization of protein-cysteine farnesyltransferase.". Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7541–5. PMID 2217184.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Sinensky M, Fantle K, Trujillo M, et al. (1994). "The processing pathway of prelamin A.". J. Cell. Sci. 107 ( Pt 1): 61–7. PMID 8175923.
Andres DA, Milatovich A, Ozçelik T, et al. (1994). "cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences.". Genomics 18 (1): 105–12. doi:10.1006/geno.1993.1432. PMID 8276393.
Omer CA, Kral AM, Diehl RE, et al. (1993). "Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases.". Biochemistry 32 (19): 5167–76. PMID 8494894.
Wang T, Danielson PD, Li BY, et al. (1996). "The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling.". Science 271 (5252): 1120–2. PMID 8599089.
Nantais DE, Schwemmle M, Stickney JT, et al. (1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1.". J. Leukoc. Biol. 60 (3): 423–31. PMID 8830800.
Goalstone ML, Draznin B (1996). "Effect of insulin on farnesyltransferase activity in 3T3-L1 adipocytes.". J. Biol. Chem. 271 (44): 27585–9. PMID 8910345.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Long SB, Casey PJ, Beese LS (1998). "Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.". Biochemistry 37 (27): 9612–8. doi:10.1021/bi980708e. PMID 9657673.
Prakash B, Praefcke GJ, Renault L, et al. (2000). "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins.". Nature 403 (6769): 567–71. doi:10.1038/35000617. PMID 10676968.
Zeng Q, Si X, Horstmann H, et al. (2000). "Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome.". J. Biol. Chem. 275 (28): 21444–52. doi:10.1074/jbc.M000453200. PMID 10747914.
Ashar HR, James L, Gray K, et al. (2000). "Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules.". J. Biol. Chem. 275 (39): 30451–7. doi:10.1074/jbc.M003469200. PMID 10852915.
Guenzi E, Töpolt K, Cornali E, et al. (2001). "The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines.". EMBO J. 20 (20): 5568–77. doi:10.1093/emboj/20.20.5568. PMID 11598000.
Long SB, Hancock PJ, Kral AM, et al. (2001). "The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.". Proc. Natl. Acad. Sci. U.S.A. 98 (23): 12948–53. doi:10.1073/pnas.241407898. PMID 11687658.
Lobell RB, Omer CA, Abrams MT, et al. (2002). "Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.". Cancer Res. 61 (24): 8758–68. PMID 11751396.
Bell IM, Gallicchio SN, Abrams M, et al. (2002). "3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.". J. Med. Chem. 45 (12): 2388–409. PMID 12036349.
Long SB, Casey PJ, Beese LS (2002). "Reaction path of protein farnesyltransferase at atomic resolution.". Nature 419 (6907): 645–50. doi:10.1038/nature00986. PMID 12374986.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
deSolms SJ, Ciccarone TM, MacTough SC, et al. (2003). "Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.". J. Med. Chem. 46 (14): 2973–84. doi:10.1021/jm020587n. PMID 12825937.