From Wikipedia, the free encyclopedia
| FMN riboswitch (RFN element) |
 |
| Type: |
Cis-reg; riboswitch; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
Vitreshchak A |
| Avg length: |
144.7 nucleotides |
| Avg identity: |
65% |
|
The FMN riboswitch (also known as RFN element) is a highly conserved RNA element that is found frequently in the 5'-untranslated regions of prokaryotic mRNAs that encode for flavin mononucleotide (FMN) biosynthesis and transport proteins. This element is a metabolite-dependent riboswitch that directly binds FMN in the absence of proteins. In Bacillus subtilis, the riboswitch most likely controls gene expression by causing premature transcription termination within the 5' untranslated region of the ribDEAHT operon and precluding access to the ribosome-binding site of ypaA mRNA.[1]
[edit] References
- ^ Winkler, WC; Cohen-Chalamish S, Breaker RR (2002). "An mRNA structure that controls gene expression by binding FMN". Proc Natl Acad Sci U S A 99: 15908–15913. doi:10.1073/pnas.212628899. PMID 12456892.
- Vitreschak, AG; Rodionov DA, Mironov AA, Gelfand MS (2002). "Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation". Nucleic Acids Res 30: 3141–3151. doi:10.1093/nar/gkf433. PMID 12136096.
- Gelfand, MS; Mironov AA, Jomantas J, Kozlov YI, Perumov DA (1999). "A conserved RNA structure element involved in the regulation of bacterial riboflavin synthesis genes". Trends Genet 15: 439–442. doi:10.1016/S0168-9525(99)01856-9. PMID 10529804.
[edit] External links
