Talk:Fluticasone
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[edit] Can
Can we please remove the list of clinical trials. This is an encyclopedia, not a meta-analysis. JFW | T@lk 20:24, 10 May 2005 (UTC)
[edit] Advair
Just an FYI for those who watch this article, fluticasone propionate is one of the two active ingredients in Advair (Fluticasone/salmeterol).
[edit] Flovent
It would be nice if somebody could detail the situation by which the Flovent MDI inhaler is now off patent, but GSK removed the Flovent MDI product from the market and replaced it with the Flovent HFA inhaler. Since the CFC-containing MDI inhalers are being phased out, perhaps generic drug makers beleaved that they would not be able to receive approval. This is unfortunate, because consumers do not have the lower-cost generic option for this long-term medication like they do with generic albuterol inhalers (which server a different function).
[edit] Beconase?
Where is fluticasone sold as Beconase? At least here in the US, Beconase is beclomethasone.
- Agree likewise so in UK. "Beconae" was added in this edit. I have removed it for now. David Ruben Talk 13:10, 22 September 2006 (UTC)
- That addition was mine: in Australia, two preparations of Beconase are sold: a "12 hour" version containing beclomethasone dipropionate, and a "24 hour" version with fluticasone propionate. Ben White 00:45, 14 October 2006 (UTC)
- In Australia, formulated fluticasone propionate is sold as "Beconase allergy". "Beconase" contains only beclomethasone. —Preceding unsigned comment added by 198.28.69.5 (talk) 05:10, 12 November 2007 (UTC)
[edit] Mechanism
If anybody wants to know the mechanism, Please refer to the following article:
J Allergy Clin Immunol. 2004 Aug;114(2):296-301 Fluticasone propionate increases CD4CD25 T regulatory cell suppression of allergen-stimulated CD4CD25 T cells by an IL-10-dependent mechanism. Dao Nguyen X, Robinson DS. PMID 15316506 dtzur@ualberta.ca
- Yet note that this only a possible mechanism - as the abstract states "CONCLUSION: Increased suppression by CD4+CD25+ T cells might play a role in anti-inflammatory effects of corticosteroids in asthma and allergic diseases" David Ruben Talk 22:21, 17 October 2006 (UTC)
I believe the place for addressing the possible mechinisms (+ side effects) of inhaled corticosteroids should be via a link - having seperate explanations for every distinct drug is inefficient.
the only distinct difference that I am aware of with fluticasone is that it has less systemic absorbtion than the other inhaled steroids, theoretically decreasing the incidence of growth supression and supression of the adrenocorticoid axis. I have not put this in the article as I do not have a good reference off the top of my head. Whyso 14:25, 29 December 2006 (UTC)
[edit] Branding
the article states: "It is marketed with the brand name Flixotide and Flixonase by Allen & Hanburys and Flovent and Flonase by GlaxoSmithKline.". But I have a bottle here (New Zealand) called Flixonase (TM), and it is made by GlaxoSmithKline and even says Flixonase and the logo are are trademarks of GlaxoSmithKline. Did gsk buy out Allen & Hanburys? or is this just wrong? Onco_p53 10:44, 29 November 2006 (UTC)
Yes. No. Axl 13:29, 23 February 2007 (UTC)
[edit] Urgent correction
I'm not knowledgeable enough about the markup language to do this myself. This page is about "fluticasone" and the structure is correctly depicted.
However, all the drug products mentioned: Flonase, Flixotide, Flixonase, Cutivate, etc. use "fluticasone propionate". Fluticasone and fluticasone propionate are different chemical entities; the latter has the tertiary hydroxyl propiolated.
As far as I know, there are no drug products out there using fluticasone. Quite often "fluticasone propionate" is referred to as "fluticasone" in shorthand, which is where the confusion arises. Now there is also "fluticasone furoate" which has the tertiary hydroxyl furoylated. 198.28.69.5 02:07, 15 November 2007 (UTC)
