Fluoroacetaldehyde dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a fluoroacetaldehyde dehydrogenase (EC 1.2.1.69) is an enzyme that catalyzes the chemical reaction

fluoroacetaldehyde + NAD⁺ + H₂O fluoroacetate + NADH + 2 H⁺

The 3 substrates of this enzyme are fluoroacetaldehyde, NAD⁺, and H₂O, whereas its 3 products are fluoroacetate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is fluoroacetaldehyde:NAD+ oxidoreductase.

[edit] References

• IUBMB entry for 1.2.1.69
• BRENDA references for 1.2.1.69 (Recommended.)
• PubMed references for 1.2.1.69
• PubMed Central references for 1.2.1.69
• Google Scholar references for 1.2.1.69
• Murphy CD, Moss SJ, O'Hagan D (2001). "Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya". Appl. Environ. Microbiol. 67: 4919–21. doi:10.1128/AEM.67.10.4919-4921. PMID 11571203. 
• Murphy CD, Schaffrath C, O'Hagan D (2003). "Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya". Chemosphere. 52: 455–61. doi:10.1016/S0045-6535(03)00191-7. PMID 12738270. 

[edit] External links

• IUBMB entry for 1.2.1.69

• KEGG entry for 1.2.1.69

• BRENDA entry for 1.2.1.69

• NiceZyme view of 1.2.1.69

• EC2PDB: PDB structures for 1.2.1.69

• PRIAM entry for 1.2.1.69

• PUMA2 entry for 1.2.1.69

• IntEnz: Integrated Enzyme entry for 1.2.1.69

• MetaCyc entry for 1.2.1.69

• Atomic-resolution structures of enzymes belonging to this class