FluidSynth
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FluidSynth, formerly known as iiwusynth, is the name of a free, open source program which synthesizes using SoundFont technology without need for a SoundFont-compatible soundcard, and the size of loaded SoundFont banks is limited by the amount of RAM available. There is a GUI for FluidSynth called Qsynth which is also open source. Both are available in most Linux distributions; compiling them for Windows is also possible.
It features microtonal support and was used in the MicrotonalISM project of the Network for Interdisciplinary Studies in Science, Technology, and Music.[1]