FLT1

From Wikipedia, the free encyclopedia

Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

PDB rendering based on 1flt.

Available structures: 1flt, 1qsv, 1qsz, 1qty, 1rv6

Identifiers

Symbol(s)

FLT1; FLT; VEGFR1

External IDs

OMIM: 165070 MGI: 95558 HomoloGene: 20463

Gene ontology
Molecular Function:	• nucleotide binding • receptor activity • vascular endothelial growth factor receptor activity • ATP binding • transferase activity • identical protein binding
Cellular Component:	• extracellular space • integral to plasma membrane • membrane
Biological Process:	• patterning of blood vessels • protein amino acid phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • multicellular organismal development • female pregnancy • positive regulation of cell proliferation • cell migration • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002019 (mRNA)
NP_002010 (protein)

NM_010228 (mRNA)
NP_034358 (protein)

Location

Chr 13: 27.77 - 27.97 Mb

Chr 5: 147.87 - 148.04 Mb

Pubmed search

[1]

[2]

Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), also known as FLT1, is a human gene.

Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM]^[1]

[edit] See also

VEGF receptors

[edit] References

^ Entrez Gene: FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor).

[edit] Further reading

Petrova TV, Makinen T, Alitalo K (1999). "Signaling via vascular endothelial growth factor receptors.". Exp. Cell Res. 253 (1): 117-30. doi:10.1006/excr.1999.4707. PMID 10579917.
Sato Y, Kanno S, Oda N, et al. (2000). "Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction.". Ann. N. Y. Acad. Sci. 902: 201-5; discussion 205-7. PMID 10865839.
Boyd AW, Lackmann M (2002). "Signals from Eph and ephrin proteins: a developmental tool kit.". Sci. STKE 2001 (112): RE20. doi:10.1126/stke.2001.112.re20. PMID 11741094.
Luttun A, Tjwa M, Carmeliet P (2003). "Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders.". Ann. N. Y. Acad. Sci. 979: 80-93. PMID 12543719.
Maynard SE, Venkatesha S, Thadhani R, Karumanchi SA (2005). "Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia.". Pediatr. Res. 57 (5 Pt 2): 1R-7R. doi:10.1203/01.PDR.0000159567.85157.B7. PMID 15817508.
Shibuya M (2007). "Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis.". Angiogenesis 9 (4): 225-30; discussion 231. doi:10.1007/s10456-006-9055-8. PMID 17109193.
Widmer M, Villar J, Benigni A, et al. (2007). "Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review.". Obstetrics and gynecology 109 (1): 168-80. doi:10.1097/01.AOG.0000249609.04831.7c. PMID 17197602.
López-Novoa JM (2007). "Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia.". Nephrol. Dial. Transplant. 22 (3): 712-4. doi:10.1093/ndt/gfl768. PMID 17210583.