FLRT3

From Wikipedia, the free encyclopedia

Fibronectin leucine rich transmembrane protein 3

Identifiers

External IDs

OMIM: 604808 MGI: 1918686 HomoloGene: 8322

Gene ontology
Molecular Function:	• receptor signaling protein activity • protein binding, bridging
Cellular Component:	• proteinaceous extracellular matrix • integral to plasma membrane • membrane
Biological Process:	• cell adhesion • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_013281 (mRNA)
NP_037413 (protein)

XM_001004746 (mRNA)
XP_001004746 (protein)

Location

Chr 20: 14.25 - 14.27 Mb

Chr 2: 140.34 - 140.36 Mb

Pubmed search

[1]

[2]

Fibronectin leucine rich transmembrane protein 3, also known as FLRT3, is a human gene.^[1]

FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. They may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. FLRT3 shares 55% amino acid sequence identity with FLRT1 and 44% identity with FLRT2. FLRT3 is expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: FLRT3 fibronectin leucine rich transmembrane protein 3.

[edit] Further reading

Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143–50. PMID 10819331.
Lacy SE, Bönnemann CG, Buzney EA, Kunkel LM (2000). "Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins.". Genomics 62 (3): 417–26. doi:10.1006/geno.1999.6033. PMID 10644439.